Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.

Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.
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DOI:
10.3389/fnmol.2011.00047
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发表时间:
2011
影响因子:
4.8
通讯作者:
Yang ES
Yang ES
中科院分区:
医学2区
文献类型:
--
作者:
Mills CN;Nowsheen S;Bonner JA;Yang ES

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具有结构性活性的蛋白糖原合成酶激酶3(GSK3)是一种丝氨酸/苏氨酸激酶,在一些肿瘤中发挥着矛盾的肿瘤抑制作用,而在另一些肿瘤中却促进了生长。破译是什么控制了它的行为,对于理解包括脑癌在内的许多病理情况至关重要。GSK3看似不同的作用源于GSK3对许多细胞功能的复杂调节。本文就GSK3在脑肿瘤中的调控、在生存、凋亡和DNA损伤中的作用以及其潜在的治疗作用作一综述。彻底了解这种多功能的蛋白质对于改善各种疾病,特别是癌症的预后至关重要。
The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are seemingly disparate roles of GSK3 stems from the complex regulation of many cellular functions by GSK3. This review focuses on the regulation of GSK3, its role in survival, apoptosis and DNA damage, and finally its potential therapeutic impact in brain cancer. A thorough understanding of this versatile protein is critical for improving the outcome of various diseases, especially cancer.
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