Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.
Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.
复制标题
葡萄糖预处理对猫弥漫性脑缺血恢复的有害影响。
作者：
Welsh,FA;Ginsberg,MD;Rieder,W;Budd,WW
在脑缺血之前，给猫静脉注射葡萄糖。在7个区域测量的大脑葡萄糖浓度比没有输液的动物高出2.5倍。脑缺血15或30分钟后，葡萄糖灌注组动物脑内乳酸积聚较多。与未处理的动物相比，经葡萄糖处理的动物脑缺血后再循环90分钟内的ATP、磷酸肌酸和乳酸的恢复受到严重损害。因此，过量的乳酸酸中毒可能是干扰脑缺血后代谢重建的主要因素。
Glucose was infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic acid in the brain of glucose-infused animals. Post-ischemic restitution of cerebral ATP, phosphocreatine, and lactate during 90 minutes of recirculation was severely impaired in the brain of animals pretreated with glucose compared to untreated animals. Thus, excess lactic acidosis may be a major factor interfering with metabolic restitution following cerebral ischemia.