Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with aging
Cross-sectional and longitudinal analyses of anatomical sulcal changes associated with aging
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DOI：
10.1093/cercor/bhj095
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发表时间：
2006-11-01
期刊：
影响因子：
3.7
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Rettmann, Maryam E.;Kraut, Michael A.;Resnick, Susan M.
对人脑的成像研究表明，大脑皮质在衰老过程中经历了解剖学上的变化。随着利用磁共振成像研究活体人类大脑的能力，了解这些变化的性质和位置越来越引起人们的兴趣。在这项工作中，我们研究了横截面和纵向年龄对皮质表面感兴趣区域的几何形状和灰质(GM)体积的影响。每个区域对应于围绕着脑沟间隙的埋藏的皮质，被称为“脑沟区域”。这项研究包括35名老年人，他们在四年的时间跨度内进行了三次扫描。这组人包括19名女性和16名男性，年龄从59岁到84岁(平均70.9岁，标准差6.2)。我们分析了8个脑沟区域--围绕左右中央沟、额上区、扣带区和顶枕沟周围的埋藏皮质。我们检查了表面积、GM厚度、GM体积、沟深度、局部回转指数和曲率测量。结果表明，在平均厚度、Gm体积、沟深度和沟区曲率特征上存在横截面年龄效应。此外，我们还发现表面积、平均厚度、Gm体积和脑沟深度测量的纵向减少以及脑沟曲率的变化。
Imaging studies of the human brain indicate that the cortex undergoes anatomic changes during the aging process. With the ability to study the human brain in vivo using magnetic resonance imaging, understanding the nature and location of these changes is of increasing interest. In this work, we investigate cross-sectional and longitudinal age effects on the geometric shape and gray matter (GM) volume for regions of interest on the cortical surface. Each of the regions corresponds to the buried cortex surrounding the sulcal spaces and is termed a "sulcal region." The study consists of 35 older adults scanned three times over a 4-year time span. The group includes 19 women and 16 men ranging in ages from 59 to 84 years (mean 70.9, standard deviation 6.2). We analyze 8 sulcal regions-the buried cortex surrounding the left and right central, superior frontal, cingulate, and parietooccipital sulci. We examine surface area, GM thickness, GM volume, sulcal depth, local gyrification index, and measures of curvature. Results indicate cross-sectional age effects in mean thickness, GM volume, sulcal depth, and curvature characteristics of sulcal regions. In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature.