Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus
Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus
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DOI：
10.1038/26487
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发表时间：
1998-09
期刊：
影响因子：
64.8
通讯作者：
W. Usrey;J. Reppas;R Clay;Reid
中科院分区：
文献类型：
--
作者：
W. Usrey;J. Reppas;R Clay;Reid
在许多体外研究的神经系统中，传入冲动的时间会影响突触后电位的强度。传入时序对突触后激活的影响较少受到关注。在这里，我们通过同时记录视网膜的神经节细胞及其在丘脑外侧膝状核的靶细胞来研究传入棘波计时的重要性。当来自单个神经节细胞轴突的两个棘波在30毫秒内到达彼此时，第二个棘波比第一个更有可能产生膝状棘波，我们称之为成对棘波增强。此外，来自一个神经节细胞和两个丘脑靶点的同时记录表明，成对棘波增强增加了丘脑同步活动的频率。我们认为，在单个视网膜神经节细胞的高放电频率中编码的信息将分布在几个同时放电的膝状神经元中。由于同步膝状细胞动作电位在驱动皮质神经元方面非常有效，因此由这一策略编码的信息很可能被传递到下一级处理。
In many neural systems studiedin vitro, the timing of afferent impulses affects the strength of postsynaptic potentials,. The influence of afferent timing on postsynaptic firingin vivohas received less attention. Here we study the importance of afferent spike timingin vivoby recording simultaneously from ganglion cells in the retina and their targets in the lateral geniculate nucleus of the thalamus. When two spikes from a single ganglion-cell axon arrive within 30 milliseconds of each other, the second spike is much more likely than the first to produce a geniculate spike, an effect we call paired-spike enhancement. Furthermore, simultaneous recordings from a ganglion cell and two thalamic targets indicate that paired-spike enhancement increases the frequency of synchronous thalamic activity. We propose that information encoded in the high firing rate of an individual retinal ganglion cell becomes distributed among several geniculate neurons that fire synchronously. Because synchronous geniculate action potentials are highly effective in driving cortical neurons, it is likely that information encoded by this strategy is transmitted to the next level of processing.