The Stillbirth Collaborative Research Network (SCRN) Placental and Umbilical Cord Examination Protocol
The Stillbirth Collaborative Research Network (SCRN) Placental and Umbilical Cord Examination Protocol
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DOI：
10.1055/s-0031-1281509
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发表时间：
2011-11-01
影响因子：
2
通讯作者：
Reddy, Uma M.
中科院分区：
文献类型：
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作者：
Pinar, Halit;Koch, Matthew A.;Reddy, Uma M.
死产合作研究网络 (SCRN) 的组织目的是研究美国死产 (SB) 的范围和原因。本报告的目的是描述作为研究一部分进行胎盘检查的方法。 SCRN 由来自五个临床中心、国家儿童健康和人类发展研究所以及数据协调和分析中心的多学科研究人员团队组成。该研究是一项基于人群的队列和巢式病例对照研究，前瞻性招募了分娩时患有 SB 和活产 (LB) 的妇女。对两组的SB和胎盘检查进行详细和标准化的尸检。共有 663 名 SB 女性和 1932 名 LB 女性参加了病例对照研究。 SB组有707个胎儿。其中，654 例（98.6%）进行了胎盘检查。在这些 LB 对照中，1804 名 (93.4%) 进行了胎盘检查。这是最大的前瞻性研究，包括基于人群的 SB 和 LB，使用标准化尸检和胎盘检查、病历审查、产妇访谈、样本收集以及多学科研究人员团队的合作分析。因此，它有可能提供关于胎盘异常对死产的影响的高水平证据。
The Stillbirth Collaborative Research Network (SCRN) was organized to study the scope and causes of stillbirth (SB) in the United States. The objective of this report is to describe the approach used for the placental examination performed as part of the study. The SCRN consists of a multidisciplinary team of investigators from five clinical sites, the National Institute of Child Health and Human Development, and the Data Coordination and Analysis Center. The study is a population-based cohort and nested case-control study, with prospective enrollment of women with SB and live births (LB) at the time of delivery. Detailed and standardized postmortem examination was performed on SB and placental examination in both groups. A total of 663 women with SB and 1932 women with LB were enrolled into the case-control study. In the SB group, there were 707 fetuses. Of these cases, 654 (98.6%) had placental examination. Of these LB controls, 1804 (93.4%) had placental examination. This is the largest prospective study to include population-based SB and LB, using standardized postmortem and placental examination, medical record review, maternal interview, collection of samples, and a multidisciplinary team of investigators collaborating in the analyses. Thus it has the potential to provide high-level evidence regarding the contribution of placental abnormalities to stillbirth.