Cognitive functioning after medial frontal lobe damage including the anterior cingulate cortex: A preliminary investigation
Cognitive functioning after medial frontal lobe damage including the anterior cingulate cortex: A preliminary investigation
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DOI：
10.1016/j.bandc.2005.11.003
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Cipolotti, L
中科院分区：
文献类型：
--
作者：
Baird, A;Dewar, BK;Cipolotti, L
两名内侧额叶损伤涉及前扣带皮层（ACC）的患者进行了一系列认知任务，包括执行功能和前注意力测试。这两名患者的病变均超出了ACC，因此，将观察到的缺陷单独归因于ACC时需要谨慎。将患者的表现与年龄和教育程度匹配的健康对照组进行比较。两名患者均表现出完整的智力、记忆和语言能力。视觉感知功能未见明显异常。仅患者2（双侧ACC病变）的信息处理速度轻度降低。患者仅在选择性执行功能测试中表现出较弱或受损的表现。前注意任务的表现令人满意。我们初步认为，我们的研究结果是不一致的前注意力理论的ACC功能的神经影像学研究结果的基础上。我们认为，这些数据可能意味着ACC在认知中没有核心作用。我们推测，我们的研究结果可能与ACC整合认知处理与自主功能来指导行为的观点一致。(c)2005年爱思唯尔公司All rights reserved.
Two patients with medial frontal lobe damage involving the anterior cingulate cortex (ACC) performed a range of cognitive tasks, including tests of executive function and anterior attention. Both patients lesions extended beyond the ACC, therefore caution needs to be exerted in ascribing observed deficits to the ACC alone. Patient performance was compared with age and education matched healthy controls. Both patients showed intact intellectual, memory, and language abilities. No clear-cut abnormalities were noted in visuoperceptual functions. Speed of information processing was mildly reduced only in Patient 2 (bilateral ACC lesion). The patients demonstrated weak or impaired performance only on selective executive function tests. Performance on anterior attention tasks was satisfactory. We tentatively suggest that our findings are inconsistent with anterior attention theories of ACC function based on neuroimaging findings. We propose that the data may imply that the ACC does not have a central role in cognition. We speculate that our findings may be compatible with the view that the ACC integrates cognitive processing with autonomic functioning to guide behaviour. (c) 2005 Elsevier Inc. All rights reserved.