Nanoparticles modified with vasculature-homing peptides for targeted cancer therapy and angiogenesis imaging
Nanoparticles modified with vasculature-homing peptides for targeted cancer therapy and angiogenesis imaging
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DOI：
10.1016/j.jconrel.2021.08.044
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发表时间：
2021-09-03
影响因子：
10.8
通讯作者：
Valizadeh, Hadi
中科院分区：
文献类型：
--
作者：
Seyyednia, Elham;Oroojalian, Fatemeh;Valizadeh, Hadi
癌症治疗的两个主要挑战包括缺乏早期检测和具有各种副作用的无效治疗。血管生成是许多恶性肿瘤生长、存活、侵袭和转移的关键过程。血管生成的成像可以导致肿瘤的早期诊断和治疗反应的评估。新生血管表达与正常血管不同的特异性分子标记物（在水平或种类上）。这一事实将使肿瘤脉管系统成为肿瘤内靶向治疗剂和成像剂的合适部位。使用对脉管系统标志物具有高结合亲和力的肽配体的表面改性的纳米颗粒提供治疗剂和成像剂的有效递送，同时避免不期望的副作用。在这篇综述中，我们讨论了各种肿瘤靶向肽的发现，用于肿瘤血管生成成像和靶向治疗，重点是使用血管靶向肽的表面修饰纳米药物。
The two major challenges in cancer treatment include lack of early detection and ineffective therapies with various side effects. Angiogenesis is the key process in the growth, survival, invasiveness, and metastasis of many of cancerous tumors. Imaging of the angiogenesis could lead to diagnosis of tumors in the early stage and evaluation of the therapeutic responses. Angiogenic blood vessels express specific molecular markers different from normal blood vessels (in level or kind). This fact would make the tumor vasculature a suitable site to target therapeutics and imaging agents within the tumor. Surface modified nanoparticles using peptide ligands with high binding affinity to the vasculature markers, provide efficient delivery of therapeutic and imaging agents, while avoiding undesirable side effects. In this review, we discuss discoveries of various tumor targeting peptides useful for tumor angiogenesis imaging and targeted therapy with emphasis on surface modified nanomedicines using vasculature targeting peptides.