A mechanism for differential control of axonal and dendritic spiking underlying learning in a cerebellum-like circuit
A mechanism for differential control of axonal and dendritic spiking underlying learning in a cerebellum-like circuit
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DOI：
10.1016/j.cub.2023.05.040
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发表时间：
2023-07-10
期刊：
影响因子：
9.2
通讯作者：
Sawtell，Nathaniel B.
中科院分区：
文献类型：
--
作者：
Muller，Salomon Z.;Abbott，L. F.;Sawtell，Nathaniel B.
除了用于轴突信号传导的动作电位之外，许多神经元产生与突触可塑性相关的树突“尖峰”。然而，为了控制可塑性和信号，突触输入必须能够差分调制这两种尖峰类型的发射。在这里，我们调查这个问题，在电感觉叶（ELL）的弱电？鱼，在轴突和树突棘的单独控制是必不可少的学习预测信号的传输从抑制性中间神经元的输出阶段的电路。通过实验和建模研究相结合，我们发现了一种新的机制，通过这种机制，感觉输入选择性地调节树突尖峰的速度，通过调整反向传播轴突动作电位的幅度。有趣的是，这种机制不需要空间隔离的突触输入或树突区室化，而是依赖于轴突中的一个电紧张性远距离尖峰起始位点-神经元的一个共同的生物物理特征。
In addition to the action potentials used for axonal signaling, many neurons generate dendritic "spikes" associated with synaptic plasticity. However, in order to control both plasticity and signaling, synaptic inputs must be able to differentially modulate the firing of these two spike types. Here, we investigate this issue in the electrosensory lobe (ELL) of weakly electric mormyrid fish, where separate control over axonal and dendritic spikes is essential for the transmission of learned predictive signals from inhibitory interneurons to the output stage of the circuit. Through a combination of experimental and modeling studies, we uncover a novel mechanism by which sensory input selectively modulates the rate of dendritic spiking by adjusting the amplitude of backpropagating axonal action potentials. Interestingly, this mechanism does not require spatially segregated synaptic inputs or dendritic compartmentalization but relies instead on an electrotonically distant spike initiation site in the axon—a common biophysical feature of neurons.