Is skeletal muscle ventricle chronic stability dependent on wall stress? Design implications.
Is skeletal muscle ventricle chronic stability dependent on wall stress? Design implications.
复制标题
骨骼肌心室的长期稳定性是否依赖于壁应力？
DOI：
10.1111/j.1525-1594.2006.00177.x
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Fiebig-Mathine,LeeAnn
中科院分区：
文献类型：
--
作者：
Gustafson,KennethJ;Sweeney,JamesD;Gibney,John;Fiebig-Mathine,LeeAnn
Chronic skeletal muscle ventricle (SMV) stability is essential for clinical implementation. SMVs in animal models have chronically expanded or collapsed when exposed to physiologic pressures. SMV wall stress is a more appropriate indicator than pressure or geometry to compare SMVs between studies. SMV wall tensions during conditioning were determined for SMVs that collapsed, expanded, or were isovolumetric in a previous study. Wall stresses in SMVs that expanded (2.76 ± 0.803 N/cm2) were significantly greater than isovolumetric SMVs (0.89 ± 0.450) and SMVs that collapsed (0.88 ± 0.451). These data support the existence of minimum and maximum wall stresses for SMV volume stability and provide empiric estimates for SMV design. Scaling SMV designs from animal models with smaller volumes and similar pressures may result in greater wall stresses in clinical designs. Therefore, the use of volume limiting implants or an isovolumetric conditioning phase to increase the wall stress expansion threshold may be required.
