Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology.
Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology.
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DOI：
10.1158/1078-0432.ccr-16-0573
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发表时间：
2016-07-15
期刊：
影响因子：
--
通讯作者：
Grizzle WE
中科院分区：
文献类型：
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作者：
McNally LR;Mezera M;Morgan DE;Frederick PJ;Yang ES;Eltoum IE;Grizzle WE
癌症的准确检测和表征是提供及时干预和有效治疗的关键。目前的成像技术在检测体内非常小的肿瘤（即非常早期的癌症或转移）、区分存活肿瘤与周围死亡肿瘤组织以及评估组织内的肿瘤代谢方面特别有限。光声成像为这些成像问题提供了潜在的解决方案，因为其能够在不涉及电离辐射的情况下对内在组织发色团和外源性造影剂的光学吸收特性进行成像。光声成像使用脉冲激光来诱导局部热弹性膨胀，该局部热弹性膨胀产生可由超声换能器检测的声波。迄今为止，多光谱光声断层扫描（MSOT）主要用于临床前研究;然而，其在转化和临床研究中的应用正在扩大。本文综述了目前和新兴的应用光声成像的分子成像的癌症使用外源性和内源性造影剂，并揭示了潜在的未来的临床应用。
Accurate detection and characterization of cancers is key for providing timely intervention and effective treatments. Current imaging technologies are particularly limited when it comes to detecting very small tumors in vivo, i.e. very early cancers or metastases, differentiating viable tumor from surrounding dead tumor tissue, and evaluating tumor metabolism within tissue. Optoacoustic imaging offers potential solutions to these imaging problems because of its ability to image optical absorption properties of both intrinsic tissue chromophores and exogenous contrast agents without the involvement of ionizing radiation. Optoacoustic imaging uses pulsed laser to induce localized thermoelastic expansion that generates acoustic waves detectable by an ultrasound transducer. To date, Multispectral optoacoustic tomography (MSOT) has primarily been utilized in preclinical research; however, its use in translational and clinical research is expanding. This review focuses on the current and emerging applications of optoacoustic imaging for the molecular imaging of cancer using both exogenous and endogenous contrast agents and sheds light on potential future clinical applications.