Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism
Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism
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DOI：
10.1016/j.thromres.2011.01.002
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发表时间：
2011-05-01
影响因子：
7.5
通讯作者：
Simioni, Paolo
中科院分区：
文献类型：
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作者：
Campello, Elena;Spiezia, Luca;Simioni, Paolo
背景：癌症是一种血栓前状态，静脉血栓栓塞（VTE）的患病率增加。微粒（MP）是来自活化或凋亡细胞的亚微米大小的囊泡，可能在VTE中发挥作用，尽管这种关联的证据仍然有限。目的：评估血浆中内皮细胞（EMPs）、血小板（PMPs）和携带组织因子的MP（TF（+）MP）数量增加可能有助于癌症相关血栓形成的假设。对我科连续收治的90例患者（30例首次发生无诱因VTE; 30例活动性癌症; 30例诊断为与活动性癌症相关的急性VTE）和90例健康受试者（对照组）的EMPs、PMPs和TF（+）MPs血浆水平进行测定。结果：病例组循环血浆EMP和PMPs水平（分别为920+/-341和1221+/-413 MP/mu L）显著高于对照组（分别为299+/-102和495+/-241 MP/mu L; P < 0.05）。
Background: Cancer is a prothrombotic state, with an increased prevalence of venous thromboembolism (VTE). Microparticles (MPs) are sub-micron-sized vesicles derived from activated or apoptotic cells that may play a role in VTE, although evidence of this association is still limited.Objectives: To evaluate the hypothesis that elevated numbers of endothelial (EMPs), platelets (PMPs), and Tissue Factor-bearing MPs (TF(+)MPs) in plasma may contribute to cancer-associated thrombosis.Patients/Methods: EMPs, PMPs and TF(+)MPs plasma levels were measured in 90 consecutive patients (cases) referred to our Department (30 with a first episode of unprovoked VTE; 30 with active cancer; 30 with a diagnosis of acute VTE associated with active cancer), and in a group of 90 healthy subjects (controls). MPs analyses were performed by flow-cytometry (Cytomics FC500).Results: Cases showed statistically significant higher (mean+/-SD) circulating EMPs and PMPs plasma levels (920+/-341 and 1221+/-413 MP/mu L, respectively) than controls (299+/-102 and 495+/-241 MP/mu L; p