Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
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DOI：
10.1101/cshperspect.a012427
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Bassler, Bonnie L.
中科院分区：
文献类型：
--
作者：
Rutherford, Steven T.;Bassler, Bonnie L.
群体感应是一种细胞间的交流过程，允许细菌分享有关细胞密度的信息，并相应地调节基因表达。只有当这些过程对环境或宿主的影响最大化时，这种过程才能使细菌将耗能巨大的过程作为一个集体来表达。在由群体感应控制的许多特征中，有一种是病原菌表达毒力因子。在这里，我们回顾了金黄色葡萄球菌、蜡状芽孢杆菌、铜绿假单胞菌和霍乱弧菌的群体感应回路。我们概述了这些典型的群体感应机制，以及每种机制如何独特地控制毒力因子的产生。此外，我们还检查了最近抑制这些病原体群体感应的努力，目的是设计新的抗菌疗法。
Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally, we examine recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.