NON-DOSE-RELATED SIDE-EFFECTS OF VALPROATE
NON-DOSE-RELATED SIDE-EFFECTS OF VALPROATE
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DOI：
10.1111/j.1528-1157.1984.tb05638.x
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发表时间：
1984-01-01
期刊：
影响因子：
5.6
通讯作者：
JEAVONS, PM
中科院分区：
文献类型：
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作者：
JEAVONS, PM
本文回顾了88例丙戊酸盐肝毒性患者的临床和组织学结果。特征性病变为微泡状脂肪变性。肝毒性似乎是一种特殊反应，最有可能出现在治疗开始后的6个月内，特别是在出现粉刺的年轻患者中。如果出现急性胃肠道症状、嗜睡或嗜睡、黄疸或癫痫模式改变的患者立即停药，这种情况可能是可逆的。临床监测比实验室监测更重要。对344名在妊娠早期接受丙戊酸盐治疗的妇女的妊娠结局进行了回顾。正常婴儿225例，异常婴儿68例。丙戊酸盐在神经管缺陷病因学中的作用仍不确定，但接受丙戊酸盐治疗的母亲应该接受产前咨询。
The clinical and histological findings in 88 patients in whom hepatotoxicity with valproate has been reported were reviewed. The characteristic lesion is microvesicular steatosis. Hepatotoxicity appears to be an idiosyncratic reaction and is most likely to appear within 6 months from the start of therapy, especially in young patients on comedication. The condition may be reversible if the drug is immediately withdrawn in patients who show acute gastrointestinal symptoms, drowsiness or lethargy, jaundice, or change in seizure pattern. Clinical monitoring is more important than laboratory monitoring. The outcome of pregnancies in 344 women who received valproate in the first trimester was reviewed. There were 225 normal babies and 68 abnormal babies. The role of valproate in the aetiology of neural tube defects remains uncertain, but mothers treated with valproate should receive prenatal counselling.