Painful small-fiber neuropathy in Sjogren syndrome
Painful small-fiber neuropathy in Sjogren syndrome
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DOI：
10.1212/01.wnl.0000176034.38198.f9
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发表时间：
2005-09-27
期刊：
影响因子：
9.9
通讯作者：
Logigian, EL
中科院分区：
文献类型：
--
作者：
Chai, J;Herrmann, DN;Logigian, EL
在20例连续的干燥神经病患者中，16例（80%）表现为足部烧灼感，12例（60%）表现为非长度依赖性感觉症状。13例患者（包括7例电生理正常的患者）的小腿和大腿皮肤活检显示表皮神经纤维（ENF）密度降低或形态异常。ENF的丢失通常是非长度依赖性的，这表明患有这种疾病的患者通常患有小纤维感觉神经元病，而不是“回退”轴突病。
Of 20 consecutive patients with Sjogren neuropathy, 16 (80%) presented with burning feet and 12 (60%) with non-length-dependent sensory symptoms. Leg and thigh skin biopsies, performed in 13 patients, including 7 with normal electrophysiology, showed either reduced epidermal nerve fiber (ENF) density or abnormal morphology. ENF loss was frequently non length dependent, suggesting that patients with this disorder commonly have a small-fiber sensory neuronopathy rather than a "dying-back" axonopathy.