Low platelet count is associated with ductus arteriosus patency in preterm newborns
Low platelet count is associated with ductus arteriosus patency in preterm newborns
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DOI：
10.1016/j.earlhumdev.2012.05.007
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发表时间：
2012-10-01
影响因子：
2.5
通讯作者：
Dilmen, Ugur
中科院分区：
文献类型：
--
作者：
Dizdar, Evrim Alyamac;Ozdemir, Ramazan;Dilmen, Ugur
背景/目的：为了确定是否有血小板计数和动脉导管未闭（PDA）的发病率和/或关闭在早产新生儿之间的关联研究设计和科目：早产儿与血流动力学显着PDA（n=154）和对照组没有PDA（n=207）谁是在新生儿重症监护病房住院进行了回顾性评价。记录两组婴儿出生后3 d内血小板计数及血小板平均体积（MPV）、血小板分布宽度（PDW）等血小板指标。结果：PDA患儿的中位胎龄为26-29周（28周），出生体重为892-1250 g（1060 g）。患者组血小板计数明显低于对照组（p
Background/aim: To determine whether there is an association between platelet counts and patent ductus arteriosus (PDA) incidence and/or closure in preterm newborns.Study design and subjects: Premature infants with hemodynamically significant PDA (n=154) and a control group without PDA (n=207) who were hospitalized in the NICU were retrospectively evaluated. Platelet counts and other platelet indices including mean platelet volume (MPV) and platelet distribution width (PDW) of the infants in both groups during the first 3 days of life were recorded. Ibuprofen was started in infants with hemodynamically significant PDA and echocardiography was repeated 48 h thereafter to assess the closure of ductus.Results: Median gestational age and birth weight of the infants with PDA were 28 (range 26-29) weeks and 1060 (range 892-1250) g respectively. Platelet counts were significantly lower in the patient group than in the control group (p