Enteric immunization: Promises and challenges
Enteric immunization: Promises and challenges
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DOI：
10.1159/000171550
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发表时间：
1996-05-01
影响因子：
2.3
通讯作者：
Brown, WR
中科院分区：
文献类型：
--
作者：
Brown, WR
预防许多肠道感染的免疫接种是不够的，因为大多数可用的疫苗都是肠胃外接种的，这种途径不能有效地刺激肠道免疫系统。因此，研究人员正在寻求通过口服免疫实现肠道保护的几种策略。最有前途的方法是将免疫原掺入微粒中以保护和增强肠道淋巴组织对免疫原的摄取，微生物的遗传操作和粘膜佐剂的使用。对肠道感染进行有效的口服免疫接种，可以控制严重的腹泻病，这仍然是一个主要的世界性健康问题。
Immunization to prevent many intestinal infections is inadequate because most available vaccines are given parenterally, a route that does not effectively stimulate the intestinal immune system. Thus, investigators are pursuing several strategies for achieving enteric protection through oral immunization. The most promising approaches are the incorporation of immunogens into microparticles for protection and enhanced uptake of the immunogen by intestinal lymphoid tissues, the genetic manipulation of microorganisms, and the use of mucosal adjuvants. The achievement of effective oral immunization against intestinal infections could lead to control of serious diarrheal illnesses, which still are a major worldwide health problem.