Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
复制标题
量化先前乙酰水杨酸对脓毒症相关死亡的影响：使用倾向匹配的个体患者数据荟萃分析。
DOI：
10.1097/ccm.0000000000002654
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发表时间：
2017
影响因子：
8.8
通讯作者：
McAuley,
中科院分区：
文献类型：
--
作者：
Trauer,James;Muhi,Stephen;McBryde,EmmaS;AlHarbi,ShmeylanA;Arabi,YaseenM;Boyle,AndrewJ;Cartin-Ceba,Rodrigo;Chen,Wei;Chen,Yung-Tai;Falcone,Marco;Gajic,Ognjen;Godsell,Jack;Gong,MichelleNg;Kor,Daryl;Lösche,Wolfgang;McAuley,
Objective:The primary objective was to conduct a meta-analysis on published observational cohort data describing the association between acetyl-salicylic acid (aspirin) use prior to the onset of sepsis and mortality in hospitalized patients.Study Selection:Studies that reported mortality in patients on aspirin with sepsis with a comparison group of patients with sepsis not on prior aspirin therapy were included.Data Sources:Fifteen studies described hospital-based cohorts (n= 17,065), whereas one was a large insurance-based database (n= 683,421). Individual-level patient data were incorporated from all selected studies.Data Extraction:Propensity analyses with 1: 1 propensity score matching at the study level were performed, using the most consistently available covariates judged to be associated with aspirin. Meta-analyses were performed to estimate the pooled average treatment effect of aspirin on sepsis-related mortality.Data Synthesis:Use of aspirin was associated with a 7%(95% CI, 2–12%; p= 0.005) reduction in the risk of death as shown by meta-analysis with considerable statistical heterogeneity (I 2= 61.6%).Conclusions:These results are consistent with effects ranging from a 2% to 12% reduction in mortality risk in patients taking aspirin prior to sepsis onset. This association anticipates results of definitive studies of the use of low-dose aspirin as a strategy for reduction of deaths in patients with sepsis.
