O'nyong-nyong fever in south-central Uganda, 1996-1997: Clinical features and validation of a clinical case definition for surveillance purposes
O'nyong-nyong fever in south-central Uganda, 1996-1997: Clinical features and validation of a clinical case definition for surveillance purposes
复制标题
DOI：
10.1086/313462
复制
发表时间：
1999-11-01
影响因子：
11.8
通讯作者：
Campbell, GL
中科院分区：
文献类型：
--
作者：
Kiwanuka, N;Sanders, EJ;Campbell, GL
O 'nyong-nyong（ONN）热是由蚊子传播的中非甲病毒感染引起的一种急性、非致命性疾病，其特征为多关节痛。在391人接受采访和采样，40例确诊病例和21例推定的，充分的特点急性，最近，或以前的ONN热确定通过积极的病例发现工作或在家庭血清学调查和临床和实验室标准的应用。在确诊病例中，膝盖和脚踝是最常见的关节。关节痛的中位持续时间为6天（范围，2-21天），制动的中位持续时间为4天（范围，1-14天）。在大多数情况下，报告了全身皮疹，近一半有淋巴结病，主要是颈部。在16例病例中记录了病毒血症，主要发生在患病的前3天，其中一些病例的体温正常。在这次流行中，发热、关节痛和淋巴结病的组合在识别ONN发热病例中的特异性为83%，敏感性为61%，因此可用于监测目的。
O'nyong-nyong (ONN) fever, caused by infection with a mosquito-borne central African alphavirus, is an acute, nonfatal illness characterized by polyarthralgia, During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. Among 391 persons interviewed and sampled, 40 cases of confirmed and 21 of presumptive, well-characterized acute, recent, or previous ONN fever were identified through active case-finding efforts or during a household serosurvey and by the application of clinical and laboratory criteria. Among confirmed cases, the knees and ankles were the joints most commonly affected. The median duration of arthralgia was 6 days (range, 2-21 days) and of immobilization was 4 days (range, 1-14 days). In the majority, generalized skin rash was reported, and nearly half had lymphadenopathy, mainly of the cervical region. Viremia was documented in 16 cases, primarily during the first 3 days of illness, and in some of these, body temperature was normal. During this epidemic, the combination of fever, arthralgia, and lymphadenopathy had a specificity of 83% and a sensitivity of 61% in the identification of cases of ONN fever and thus could be useful for surveillance purposes.