Does oxidative stress shorten telomeres?
Does oxidative stress shorten telomeres?
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DOI：
10.1098/rsbl.2017.0164
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发表时间：
2017-05-01
期刊：
影响因子：
3.3
通讯作者：
Verhulst, Simon
中科院分区：
文献类型：
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作者：
Boonekamp, Jelle J.;Bauch, Christina;Verhulst, Simon
氧化应激缩短细胞培养中的端粒，但氧化应激是否能解释体内生理氧化应激水平下端粒缩短的变化尚不清楚。因此，我们测试了6个氧化应激标志物和端粒磨损之间的相关性，在雏鸟（寒鸦），表现出很高的端粒磨损率在生命早期。在5至30日龄之间测量端粒磨损，并且是高度可变的（平均端粒损失：323 bp，CV = 45%）。在20日龄时测量血液中的氧化应激标志物，包括氧化损伤标志物（TBARS、dROM和GSSG）和抗氧化保护标志物（GSH、氧化还原状态、尿酸）。端粒磨损的变化与这些氧化应激标志物无显著相关（竖线与竖线
Oxidative stress shortens telomeres in cell culture, but whether oxidative stress explains variation in telomere shortening in vivo at physiological oxidative stress levels is not well known. We therefore tested for correlations between six oxidative stress markers and telomere attrition in nestling birds (jackdaws Corvus monedula) that show a high rate of telomere attrition in early life. Telomere attrition was measured between ages 5 and 30 days, and was highly variable (average telomere loss: 323 bp, CV = 45%). Oxidative stress markers were measured in blood at age 20 days and included markers of oxidative damage (TBARS, dROMs and GSSG) and markers of antioxidant protection (GSH, redox state, uric acid). Variation in telomere attrition was not significantly related to these oxidative stress markers (vertical bar r vertical bar