Global Burden of Skin Disease as Reflected in Cochrane Database of Systematic Reviews
Global Burden of Skin Disease as Reflected in Cochrane Database of Systematic Reviews
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DOI：
10.1001/jamadermatol.2014.709
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发表时间：
2014-09-01
期刊：
影响因子：
10.9
通讯作者：
Dellavalle, Robert P.
中科院分区：
文献类型：
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作者：
Karimkhani, Chante;Boyers, Lindsay N.;Dellavalle, Robert P.
重要性研究的优先次序应该由疾病的影响来指导。目的确定科克伦系统评价数据库（CDSR）中的系统评价和方案主题是否反映了疾病负担，由全球疾病负担（GBD）2010项目中的残疾调整生命年（DIMs）来衡量。两名研究者从2013年11月1日至2013年12月6日独立评估了CDSR中的15种皮肤状况，以进行系统评价和方案说明。这15种皮肤病与2010年GBD中的相应疾病相匹配。还获得了科克伦皮肤组（CSG）发表的所有综述和方案的官方出版报告，以确保没有遗漏标题。除了研究人员外，没有其他研究参与者，他们使用数据库评估CDSR和GBD 2010皮肤状况残疾数据。主要结果和指标（系统评价和方案），占2010年DALY总数的百分比，2010年DALY排名，结果15种皮肤病在CDSR中至少有1篇系统评价; CSG的69%的系统综述和67%的方案涵盖了15种皮肤病。比较综述/方案和残疾的数量，皮炎、黑色素瘤、非黑色素瘤皮肤癌、病毒性皮肤病和真菌性皮肤病匹配良好。当与相应的褥疮匹配时，褥疮、银屑病和麻风表现出审查/方案的高代表性。相比之下，寻常痤疮，细菌性皮肤病，荨麻疹，瘙痒症，疥疮，蜂窝组织炎，斑秃在CDSR中的代表性不足时，匹配相应的DALYs.CONCLUSIONS和相关性程度的代表性在CDSR部分与DALY指标。发表的综述/方案的数量与15种研究皮肤病中5种的残疾指标匹配良好，而3种皮肤病代表性过高，7种代表性不足。我们的结果提供了高质量和透明的数据，为未来的优先级决策提供信息。
IMPORTANCE Research prioritization should be guided by impact of disease.OBJECTIVE To determine whether systematic reviews and protocol topics in Cochrane Database of Systematic Reviews (CDSR) reflect disease burden, measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 project.DESIGN, SETTING, AND PARTICIPANTS Two investigators independently assessed 15 skin conditions in the CDSR for systematic review and protocol representation from November 1, 2013, to December 6, 2013. The 15 skin diseases were matched to their respective DALYs from GBD 2010. An official publication report of all reviews and protocols published by the Cochrane Skin Group (CSG) was also obtained to ensure that no titles were missed. There were no study participants other than the researchers, who worked with databases evaluating CDSR and GBD 2010 skin condition disability data.MAIN OUTCOMES AND MEASURES Relationship of CDSR topic coverage (systematic reviews and protocols) with percentage of total 2010 DALYs, 2010 DALY rank, and DALY percentage change from 1990 to 2010 for 15 skin conditions.RESULTS All 15 skin conditions were represented by at least 1 systematic review in CDSR; 69% of systematic reviews and 67% of protocols by the CSG covered the 15 skin conditions. Comparing the number of reviews/protocols and disability, dermatitis, melanoma, nonmelanoma skin cancer, viral skin diseases, and fungal skin diseases were well matched. Decubitus ulcer, psoriasis, and leprosy demonstrated review/protocol overrepresentation when matched with corresponding DALYs. In comparison, acne vulgaris, bacterial skin diseases, urticaria, pruritus, scabies, cellulitis, and alopecia areata were underrepresented in CDSR when matched with corresponding DALYs.CONCLUSIONS AND RELEVANCE Degree of representation in CDSR is partly correlated with DALY metrics. The number of published reviews/protocols was well matched with disability metrics for 5 of the 15 studied skin diseases, while 3 skin diseases were overrepresented, and 7 were underrepresented. Our results provide high-quality and transparent data to inform future prioritization decisions.`