Curcumin-Encapsulated Hexagonal Liquid Crystalline Formed by Brij 97/NaDC Mixtures
Curcumin-Encapsulated Hexagonal Liquid Crystalline Formed by Brij 97/NaDC Mixtures
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DOI：
10.1080/01932691.2013.870042
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发表时间：
2014-08
影响因子：
2.2
通讯作者：
Xin Liu;Zhongni Wang;Lingcha Wei;Xilian Wei
中科院分区：
文献类型：
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作者：
Xin Liu;Zhongni Wang;Lingcha Wei;Xilian Wei
在25°C下测定了五组分Brij 97-NaDC/IPM-PEG 400/H2O体系的相图。在该体系中发现了六方液晶相（H1）。利用小角X射线散射（SAXS）、偏光显微镜和流变学技术，研究了组成、温度和姜黄素添加量对H1相的影响。结果表明：1）六方相液晶具有较强的剪切变稀行为和粘弹性，H1相网络的强度随含油量的增加而减弱，2）H1相液晶的频变模量随温度的升高而降低，其稳态特性粘度随温度的变化呈类Arrhenius关系;含姜黄素的H1相样品保持了有序的六方结构。小角X射线散射结果表明，姜黄素分子既可以与IPM一起溶解在圆柱体的非极性核心中，也可以溶解在圆柱体之间与PEG 400共存的极性结构域中。当姜黄素被封装在具有低油含量的样品中时，频率依赖性模量显著降低。掺入姜黄素的样品频率行为随温度变化的趋势减弱。
The phase diagram of a five-components Brij 97-NaDC/IPM-PEG 400/H2O system was determined at 25°C. The hexagonal liquid crystalline phase (H1) was found in this system. By use of small-angle x-ray scattering (SAXS), polarization microscopy, and rheology techniques, the influence of composition, temperature, and addition of curcumin on H1 phase was studied. It is shown that: 1) the investigated hexagonal liquid crystals exhibit a strong shear thinning behavior and viscoelasticity and the strength of the network of H1 phase becomes weaker with increasing oil content; 2) the frequency-dependent moduli of H1 samples decreases as the temperature increases and the steady-state limiting viscosity of the hexagonal samples shows an Arrhenius-like dependence on temperature; and 3) samples in H1 phase containing curcumin retained their organized hexagonal structure. The SAXS results show that the curcumin molecules may be solubilized both into the apolar core of cylinders together with IPM and in the polar domain coexisting with PEG 400 between the cylinders. When curcumin is encapsulated in samples with low oil content, there is a significant decrease in the frequency-dependent moduli. The tendency of frequency behavior for samples incorporating curcumin as a function of temperature is weakened.