Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
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DOI：
10.1038/srep12511
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发表时间：
2015-07-27
影响因子：
4.6
通讯作者：
Wassum KM
中科院分区：
文献类型：
--
作者：
Malvaez M;Greenfield VY;Wang AS;Yorita AM;Feng L;Linker KE;Monbouquette HG;Wassum KM
环境刺激能够产生它们所预测的奖励的具体表征，从而改变寻求奖励行为的选择和表现。基底外侧杏仁核参与了这一过程，但具体如何参与尚不清楚。为了纠正这个问题，我们在测试奖励预测线索影响奖励寻求行为（巴甫洛夫工具转移）的能力期间，近乎实时地监测基底外侧杏仁核谷氨酸浓度的变化。研究发现，在寻求工具奖励时，谷氨酸浓度会短暂升高。在巴甫洛夫工具转移测试期间，这些谷氨酸瞬变被时间锁定并仅与那些由奖励预测刺激提供的结果特定动机信息所激发的行为相关（即，获得与所呈现的 CS 预测的相同特定结果的行为）。此外，基底外侧杏仁核 AMPA 而非 NMDA 谷氨酸受体失活消除了奖赏预测线索对奖赏寻求的选择性兴奋影响。这些数据表明，BLA 中短暂的谷氨酸释放可以编码奖励预测刺激提供的特定结果的动机信息。
Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, basolateral amygdala glutamate concentration changes during a test of the ability of reward-predictive cues to influence reward-seeking actions (Pavlovian-instrumental transfer). Glutamate concentration was found to be transiently elevated around instrumental reward seeking. During the Pavlovian-instrumental transfer test these glutamate transients were time-locked to and correlated with only those actions invigorated by outcome-specific motivational information provided by the reward-predictive stimulus (i.e., actions earning the same specific outcome as predicted by the presented CS). In addition, basolateral amygdala AMPA, but not NMDA glutamate receptor inactivation abolished the selective excitatory influence of reward-predictive cues over reward seeking. These data the hypothesis that transient glutamate release in the BLA can encode the outcome-specific motivational information provided by reward-predictive stimuli.