Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
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DOI：
10.4049/jimmunol.0804249
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发表时间：
2009-05-01
期刊：
影响因子：
--
通讯作者：
Zhuang Y
中科院分区：
文献类型：
--
作者：
Ueda-Hayakawa I;Mahlios J;Zhuang Y
Most T cell progenitors develop into the αβ T cell lineage with an exception of a small fraction contributing to the γδ lineage throughout postnatal life. T cell progenitors usually commit to the αβ lineage upon the expression of a fully rearranged and functional TCRβ gene, and most cells that fail to produce a functional TCRβ chain will die instead of adopting the alternative γδ T cell fate. What prevents these cells from continuing TCRγ rearrangement and adopting the γδ T cell fate is not known. Here, we show that functional loss of Id3 results in a significant increase of γδ T cell production from progenitor cells undergoing TCRβ rearrangement. The enhanced γδ T cell development correlated with increased TCRγ gene rearrangement involving primarily Vγ1.1 in Id3 deficient mice. We further show that Id3 deficiency promotes γδ T cell production in dependent of TCRβ chain expression. Our data indicates that Id3 suppresses Vγ1.1 rearrangement and γδ lineage potential among T cell progenitors which have completed TCRβ gene rearrangement without producing a functional TCRβ protein.
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影响因子：
32.4
作者：
Ciofani, Maria;Knowles, Gisele C.;Zuniga-Pflucker, Juan Carlos
通讯作者：
Zuniga-Pflucker, Juan Carlos
DOI：
10.1073/pnas.95.21.12522
发表时间：
1998-10-13
影响因子：
11.1
作者：
Capone, M;Hockett, RD;Zlotnik, A
通讯作者：
Zlotnik, A
影响因子：
5.8
作者：
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通讯作者：
Kepler, TB
影响因子：
10.5
作者：
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通讯作者：
Hayday, AC
影响因子：
56.9
作者：
Silva-Santos, B;Pennington, DJ;Hayday, AC
通讯作者：
Hayday, AC