COCAINE-RELATED SUDDEN CARDIAC DEATH - A HYPOTHESIS CORRELATING BASIC SCIENCE AND CLINICAL OBSERVATIONS
COCAINE-RELATED SUDDEN CARDIAC DEATH - A HYPOTHESIS CORRELATING BASIC SCIENCE AND CLINICAL OBSERVATIONS
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DOI：
10.1002/j.1552-4604.1994.tb04003.x
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发表时间：
1994-09-01
影响因子：
2.9
通讯作者：
HARIMAN, RJ
中科院分区：
文献类型：
--
作者：
BAUMAN, JL;GRAWE, JJ;HARIMAN, RJ
在年轻的健康个体中，可卡因引起的突然、意外死亡以一种特殊的方式发生，通常被认为是致瘤性的，尽管死亡的确切原因很少有记录。除了间接的拟交感神经作用外，可卡因是一种有效的钠通道阻断药物，在这方面，与氟卡尼等药物最为相似。我们认为，可卡因引起的猝死在本质上是前药性的，发生在类似的情况下，由于特定的抗癫痫药物。
Sudden, unexpected death due to cocaine in young otherwise healthy individuals occurs in an idiosyncratic manner and is commonly felt to be arrhythmogenic in nature, although the exact cause of death is rarely documented. In addition to indirect sympathomimetic actions, cocaine is a potent sodium channel blocking drug and, in this regard, most closely resembles agents such as flecainide. We suggest that sudden death due to cocaine is proarrhythmic in nature, occurring under similar circumstances as that due to specific antiarrhythmic drugs.