Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study
Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study
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DOI：
10.1016/j.metabol.2007.08.022
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发表时间：
2008-02-01
影响因子：
9.8
通讯作者：
Kuller, Lewis H.
中科院分区：
文献类型：
--
作者：
Sekikawa, Akira;Ueshima, Hirotsugu;Kuller, Lewis H.
在第11次世界大战后出生队列的男性中，即40至49岁的男性中，美国白人的颈动脉内膜中层厚度（IMT）水平显著高于日本人（第11次世界大战后出生队列[ERA JUMP]研究中日本和美国男性的电子束断层扫描和风险评估）。在调整传统风险因素后，这种差异仍然存在。考虑到移居美国的日本人IMT增加的程度，原发性遗传效应不太可能。我们研究了脂蛋白亚类分布的差异是否解释了两个人群之间IMT的差异。我们研究了466名随机选择的40至49岁男性（215名来自宾夕法尼亚州阿勒格尼县的白人和241名来自日本滋贺草津的日本人）的人群样本。通过核磁共振（NMR）光谱测定脂蛋白亚类。与日本人相比，白人的大极低密度脂蛋白颗粒水平显著较高，大高密度脂蛋白颗粒水平显著较低，而两个人群的小低密度脂蛋白颗粒水平相似。这两个人群的IMT与NMR脂蛋白具有相似的相关性。校正NMR脂蛋白并没有减弱两个人群之间IMT的显著差异（白人为0.671 +/- 0.006 mm，日本人为0.618 +/- 0.006 mm，P = 0.01，平均SE）。两个人群之间NMR脂蛋白分布的差异并不能解释白人IMT较高的原因。(C)2008年爱思唯尔公司All rights reserved.
In men in the post-World War 11 birth cohort, that is, men aged 40 to 49 years, whites in the United States had significantly higher levels of intima-media thickness of the carotid arteries (IMT) than the Japanese in Japan (Electron-Beam Tomography and Risk Assessment Among Japanese and US Men in the Post World War 11 Birth Cohort [ERA JUMP] study). The difference remained after adjusting for traditional risk factors. Primary genetic effects are unlikely, given the degree to which IMT is increased in the Japanese who migrated to the United States. We investigated whether the differences in the distributions of lipoprotein subclasses explain the difference in IMT between the 2 populations. We examined population-based samples of 466 randomly selected men aged 40 to 49 years (215 whites from Allegheny County, Pennsylvania, and 241 Japanese from Kusatsu, Shiga, Japan). Lipoprotein subclasses were determined by nuclear magnetic resonance (NMR) spectroscopy. The whites had significantly higher levels of large very low-density lipoprotein particles and significantly lower levels of large high-density lipoprotein particles than the Japanese, whereas the 2 populations had similar levels of small low-density lipoprotein particles. The 2 populations had similar associations of IMT with NMR lipoproteins. Adjusting for NMR lipoproteins did not attenuate the significant difference in IMT between the 2 populations (0.671 +/- 0.006 mm for the whites and 0.618 +/- 0.006 mm for the Japanese, P = .01, mean SE). Differences in the distributions of NMR lipoproteins between the 2 populations did not explain the higher IMT in the whites. (C) 2008 Elsevier Inc. All rights reserved.