INTERSTITIAL CYSTITIS - INCREASED SYMPATHETIC INNERVATION AND RELATED NEUROPEPTIDE SYNTHESIS
INTERSTITIAL CYSTITIS - INCREASED SYMPATHETIC INNERVATION AND RELATED NEUROPEPTIDE SYNTHESIS
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DOI：
10.1016/s0022-5347(17)37314-7
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发表时间：
1992-03-01
影响因子：
6.6
通讯作者：
TANAGHO, EA
中科院分区：
文献类型：
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作者：
HOHENFELLNER, M;NUNES, L;TANAGHO, EA
为探讨间质性膀胱炎患者膀胱壁神经损害的可能性，采用免疫组织化学方法对10例间质性膀胱炎患者和10例正常对照的膀胱壁组织进行了比较。膀胱粘膜下层和逼尿肌的神经支配增强代表交感神经元的增加，而不是胆碱能神经元的增加。在间质性膀胱炎中，血管活性肠肽和神经肽Y阳性的神经元数目较多，并携带较多的轴索静脉曲张，而P物质和降钙素基因相关肽阳性的神经元数目在两组之间无显著差异。我们认为间质性膀胱炎与交感神经流入膀胱的增多和血管活性肠多肽和神经肽Y的代谢改变有关。由于在其他可能具有自身免疫性的炎症性疾病中也观察到了类似的变化，如类风湿性关节炎、克罗恩病和溃疡性结肠炎，间质性膀胱炎的病理生理可能与后者有共同的途径。这些疾病的经验可能有助于更好地了解间质性膀胱炎的病理生理学，并提出新的治疗概念。
To investigate the possibility of a neural deterioration of the bladder wall in interstitial cystitis, bladder tissue from 10 patients with interstitial cystitis was compared with that from 10 control subjects by means of immunohistochemistry. An enhanced innervation of the bladder in the submucosa and detrusor muscle was found to represent an increase of sympathetic but not cholinergic neurons. In interstitial cystitis the number of neurons positive for vasoactive intestinal polypeptide and neuropeptide Y was higher and carried a larger number of axonal varicosities, whereas the number of neurons positive for substance P and calcitonin-gene-related peptide was not significantly different in both groups. We conclude that interstitial cystitis is associated with increased sympathetic outflow into the bladder and altered metabolism of vasoactive intestinal polypeptide and neuropeptide Y. Since similar changes have been observed in other inflammatory diseases of a presumably autoimmune nature, such as rheumatoid arthritis, Crohn's disease and colitis ulcerosa, the pathophysiology of interstitial cystitis may share common pathways with the latter. Experience in these diseases may facilitate a better understanding of the pathophysiology of interstitial cystitis and suggest new therapeutic concepts.