The role of chemokines in neutrophil biology
The role of chemokines in neutrophil biology
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DOI：
10.2741/2853
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Kobayashi, Yoshiro
中科院分区：
文献类型：
--
作者：
Kobayashi, Yoshiro
中性粒细胞首先被募集到感染部位或患病部位。在各种炎症介质中，包括IL-8（CXCL 8）、MIP-2（CXCL 2）和KC（CXCL 1）的CXC趋化因子对于这种募集最关键。中性粒细胞被认为是主要通过产生活性氧来杀死细菌或破坏受影响组织的效应细胞。然而，最近的研究表明，中性粒细胞参与响应于包括LPS、TNF-α和IFN-γ在内的多种刺激物的趋化因子的产生，从而有助于免疫调节。这些功能在渗透到各个部位的过程中也受到选择素的调节。在这篇综述中，我总结了目前在这方面的知识，并提出中性粒细胞是一个迷人的目标，基础以及临床科学家。
Neutrophils are the first to be recruited to a site of infection or a diseased site. Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment. Neutrophils have been considered as effector cells that kill bacteria or destroy affected tissues mainly through the production of reactive oxygen species. Recent studies, however, revealed that neutrophils are involved in the production of chemokines in response to a variety of stimulants including LPS, TNF-alpha, and IFN-gamma, thereby contributing to immunomodulation. These functions are also regulated by selectins during infiltration into various sites. In this review, I summarize the current knowledge on this area and propose that neutrophils are a fascinating target for basic as well as clinical scientists.