Non-destructive processing of silver containing glass ceramic antibacterial coating on polymeric surgical mesh surfaces.
Non-destructive processing of silver containing glass ceramic antibacterial coating on polymeric surgical mesh surfaces.
复制标题
聚合物手术网表面含银玻璃陶瓷抗菌涂层的无损处理。
DOI：
10.1039/d3nr01317k
复制
发表时间：
2023
期刊：
影响因子：
6.7
通讯作者：
Rahimi,Rahim
中科院分区：
文献类型：
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作者：
Zareei,Amin;Kasi,Venkat;Thornton,Allison;Rivera,UlissesHeredia;Sawale,Manoj;Maruthamuthu,MuraliKannan;He,Zihao;Nguyen,Juliane;Wang,Haiyan;Mishra,DharmendraK;Rahimi,Rahim
由生物惰性聚合物（如聚丙烯）组成的外科补片广泛用于数百万例疝修补手术，以防止器官从受损腹壁突出复发。然而，术后补片感染仍然是一种严重的并发症，根据手术类型，疝复发风险从3.6%提高到10%。虽然已经尝试通过使用抗生素涂层来减轻这些感染相关的并发症，但耐药性细菌菌株的增加威胁到它们的有效性。具有贵金属，特别是银纳米颗粒（AgNPs）的生物活性玻璃陶瓷最近因其广泛的抗菌性能和生物相容性而受到关注。然而，合成和涂覆这种材料的常规方法通常需要高温，因此使得它们在温度敏感的聚合物基底上实施是不切实际的。为了规避这一挑战，已经探索了一种独特的方法来将这些功能化合物存款到温度敏感的聚丙烯网（PP-M）表面。这种方法是基于冷大气等离子体（CAP）辅助沉积SiO2薄膜和激光表面处理（LST）的最新进展，能够在大气条件下选择性加热和形成功能性玻璃陶瓷化合物。进行了一项系统研究，以确定最佳LST条件，该条件可有效形成生物活性玻璃陶瓷结构，而不会显著改变底层PP-M的化学和机械性能（与原始性能相比，变化小于1%）。在优化的工艺条件下开发的涂层表现出对革兰氏阳性菌和革兰氏阴性菌的高生物相容性和持久抗菌性能（>7天）。预计开发的过程将为在不同植入物表面沉积各种功能性生物陶瓷涂层提供新的垫脚石，从而降低感染和相关并发症的风险。
Surgical meshes composed of bioinert polymers such as polypropylene are widely used in millions of hernia repair procedures to prevent the recurrence of organ protrusion from the damaged abdominal wall. However, post-operative mesh infection remains a significant complication, elevating hernia recurrence risks from 3.6% to 10%, depending on the procedure type. While attempts have been made to mitigate these infection-related complications by using antibiotic coatings, the rise in antibiotic-resistant bacterial strains threatens their effectiveness. Bioactive glass-ceramics featuring noble metals, notably silver nanoparticles (AgNPs), have recently gained traction for their wide antibacterial properties and biocompatibility. Yet, conventional methods of synthesizing and coating of such materials often require high temperatures, thus making them impractical to be implemented on temperature-sensitive polymeric substrates. To circumvent this challenge, a unique approach has been explored to deposit these functional compounds onto temperature-sensitive polypropylene mesh (PP-M) surfaces. This approach is based on the recent advancements in cold atmospheric plasma (CAP) assisted deposition of SiO2 thin films and laser surface treatment (LST), enabling the selective heating and formation of functional glass-ceramic compounds under atmospheric conditions. A systematic study was conducted to identify optimal LST conditions that resulted in the effective formation of a bioactive glass-ceramic structure without significantly altering the chemical and mechanical properties of the underlying PP-M (less than 1% change compared to the original properties). The developed coating with optimized processing conditions demonstrated high biocompatibility and persistent antibacterial properties (>7 days) against both Gram-positive and Gram-negative bacteria. The developed process is expected to provide a new stepping stone towards depositing a wide range of functional bioceramic coatings onto different implant surfaces, thereby decreasing their risk of infection and associated complications.