Effects of Mindfulness Training on Levels of Cortisol in Cancer Patients
Effects of Mindfulness Training on Levels of Cortisol in Cancer Patients
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DOI：
10.1016/j.psym.2012.04.007
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发表时间：
2013-03-01
期刊：
影响因子：
3.4
通讯作者：
Akerstedt, Torbjorn
中科院分区：
文献类型：
--
作者：
Branstrom, Richard;Kvillemo, Pia;Akerstedt, Torbjorn
目的：本研究旨在探讨正念减压训练对癌症患者唾液皮质醇水平的影响，并进一步探讨心理变量的变化是否介导了对皮质醇的干预效果。方法：既往诊断为癌症的患者（n = 71）被招募并随机分为干预组或等待列表对照组。干预包括为期8周的MBSR培训课程。结果：在3个月或6个月的随访中，干预对皮质醇水平没有总体影响。然而，一个显着的效果，适度被发现显示不同的干预效果唤醒皮质醇的参与者之间的基线水平不同的皮质醇。在那些皮质醇初始水平较低的人中，从基线到3个月随访时皮质醇水平有所增加，而在那些皮质醇初始水平较高的人中，皮质醇水平在3个月随访时有所下降。心理结果的变化与皮质醇水平之间没有关联。结论：正念减压疗法可以调节皮质醇水平。该研究提供了初步支持，表明正念减压疗法可以影响下丘脑-垂体-肾上腺皮质（HPA）轴功能。这些研究结果的重要性，在癌症患者的正念和减压领域的未来研究进行了讨论。（Psychosomatics 2013; 54：158-164）
Objective: The aims of this study were to examine the effects of a mindfulness-based stress reduction (MBSR) training intervention among cancer patients on levels of salivary cortisol, and further to explore if changes in psychological variables mediate intervention effects on cortisol. Methods: Patients with a previous cancer diagnosis (n = 71) were recruited and randomized into an intervention group or a waiting-list control group. The intervention consisted of an 8-week MBSR training course. Results: There were no overall effects of the intervention on cortisol levels at 3-month or 6-month follow-up. However, a significant effect of moderation was found showing a different intervention effect on awakening cortisol among participants with varying baseline level of cortisol. Among those with initial low levels of cortisol, there was an increase from baseline to 3-month follow-up, and among those with initial high levels there was a decreased level of cortisol at 3-month follow-up. There was no association between changes in psychological outcomes and cortisol levels. Conclusions: The results suggest an adjustment of cortisol levels as a result of MBSR. The study gives preliminary support indicating that MBSR can influence the hypothalamic-pituitary-adrenocortical (HPA) axis functioning. The importance of these findings for future research in the field of mindfulness and stress reduction among cancer patients are discussed. (Psychosomatics 2013; 54:158-164)