Expansion of epidemic dengue viral infections to Pakistan.
Expansion of epidemic dengue viral infections to Pakistan.
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DOI：
10.1016/s1201-9712(98)90052-2
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发表时间：
1998-04-01
期刊：
影响因子：
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通讯作者：
Luby, S P
中科院分区：
文献类型：
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作者：
Paul, R E;Patel, A Y;Luby, S P
目的：在巴基斯坦偶尔有登革热病毒抗体的报告，但登革热感染在巴基斯坦的发生频率尚不清楚。巴基斯坦第一次确认的登革出血热暴发发生在1994年。1995年10月，作者调查了巴基斯坦俾路支省一家发电厂的建筑承包商雇员中爆发的发热性疾病，以确定病因并建议适当的预防措施。方法：对工作地点和生活安排进行检查，进行问卷调查，并收集所有同意在营地居住的承包商雇员及其家属的血清样本。使用酶联免疫吸附试验分析血清中抗登革热病毒的IgM。结果：共访谈76人（平均年龄42岁）；95%为男性。42人（55%）报告在前6周出现发热、头痛或肌痛。57名受试者（75%）具有针对至少一种登革热血清型的IgM抗体；45名受试者（59%）有2型登革热IgM抗体。结论：这是一起由多种血清型登革热病毒引起的登革热暴发。这证实了在巴基斯坦南部连续2年存在登革热流行感染。
OBJECTIVES: Antibodies to dengue viruses have occasionally been reported in individuals in Pakistan, but the frequency of occurrence of dengue infection in Pakistan is unclear. The first confirmed dengue hemorrhagic fever outbreak in Pakistan occurred in 1994. In October 1995, the authors investigated an outbreak of a febrile illness among employees of a construction contractor at a power generation plant in Baluchistan, Pakistan, to determine the cause of illness and recommend appropriate preventive measures.METHODS: The work site and living arrangements were inspected, a questionnaire was administered, and serum samples were collected from all consenting contractor employees and their families if they lived at the camp. Sera were analyzed for IgM against dengue virus, using an enzyme-linked immunosorbent assay.RESULTS: Interviews were conducted with 76 persons (mean age, 42y); 95% were men. Forty-two persons (55%) reported having experienced fever, headache, or myalgia in the preceding 6 weeks. Fifty-seven subjects (75%) had IgM antibodies against at least one dengue serotype; 45 subjects (59%) had IgM antibodies against dengue serotype 2.CONCLUSION: This was an outbreak of dengue fever due to multiple serotypes of dengue virus. This confirms that epidemic dengue infection was present in southern Pakistan for 2 consecutive years.