Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret.
Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret.
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DOI：
10.1016/j.colsurfb.2015.11.055
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Deng‐Guang Yu;Chen Yang;M. Jin;Gareth R. Williams;Hua Zou;Xia Wang;S. Bligh
中科院分区：
文献类型：
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作者：
Deng‐Guang Yu;Chen Yang;M. Jin;Gareth R. Williams;Hua Zou;Xia Wang;S. Bligh
一系列含药 Janus 纤维可提供高度可调的双相药物释放，采用并列静电纺丝工艺，采用聚四氟乙烯涂层平行喷丝板制造。涂覆的喷丝头促进了 Janus Taylor 锥体的形成，进而促进了高质量的集成 Janus 结构的形成，而如果没有特氟龙涂层，就无法可靠地获得这种结构。所制备的纤维一侧由聚乙烯吡咯烷酮（PVP）K60和酮洛芬组成，另一侧由乙基纤维素（EC）和酮洛芬组成。为了调节和调整药物释放，在某些情况下，将 PVP K10 掺杂到 EC 侧。纤维是线性的，具有扁平的形态，中心有凹痕。它们提供双相药物释放，PVP K60 侧非常快速地溶解以提供活性成分的负荷剂量，而 EC 侧则导致剩余酮洛芬的持续释放。 EC端加入PVP K10能够加速第二阶段的发布；掺杂剂量的变化允许精确调节该阶段的释放速率和程度。这些结果为合理设计具有高度可控药物释放曲线的系统提供了潜力，该系统可以补充自然生物节律并提供最大的治疗效果。
A family of medicated Janus fibers that provides highly tunable biphasic drug release was fabricated using a side-by-side electrospinning process employing a Teflon-coated parallel spinneret. The coated spinneret facilitated the formation of a Janus Taylor cone and in turn high quality integrated Janus structures, which could not be reliably obtained without the Teflon coating. The fibers prepared had one side consisting of polyvinylpyrrolidone (PVP) K60 and ketoprofen, and the other of ethyl cellulose (EC) and ketoprofen. To modulate and tune drug release, PVP K10 was doped into the EC side in some cases. The fibers were linear and had flat morphologies with an indent in the center. They provide biphasic drug release, with the PVP K60 side dissolving very rapidly to deliver a loading dose of the active ingredient, and the EC side resulting in sustained release of the remaining ketoprofen. The addition of PVP K10 to the EC side was able to accelerate the second stage of release; variation in the dopant amount permitted the release rate and extent this phase to be precisely tuned. These results offer the potential to rationally design systems with highly controllable drug release profiles, which can complement natural biological rhythms and deliver maximum therapeutic effects.