Functional interactions between the medial temporal lobes and posterior neocortex related to episodic memory retrieval
Functional interactions between the medial temporal lobes and posterior neocortex related to episodic memory retrieval
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DOI：
10.1093/cercor/8.5.451
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发表时间：
1998-07-01
期刊：
影响因子：
3.7
通讯作者：
Winocur, G
中科院分区：
文献类型：
--
作者：
Köhler, S;McIntosh, AR;Winocur, G
我们将结构方程模型应用于人类正电子发射断层扫描数据，以检验右侧内侧颞叶(MTL)和选定的右侧新皮质区域之间的功能相互作用与视觉识别记忆的关系。使用这些区域之间的解剖学联系的先验知识作为指导约束，我们模拟了与空间位置情景记忆提取相关的相互作用模式[即局部脑血流量的协方差]，并将其与物体身份提取的模式进行了比较。我们还将这些模式与与空间位置和对象身份的知觉匹配相关的模式进行了比较。虽然在不同任务间平均rCBF没有差异，但右侧MTL在与背后区(顶枕沟、缘上回)和腹区(梭形回、颞上沟)的相互作用中显示出领域特异性的质量差异，但与额前区没有交互作用。在空间提取任务中，涉及背侧区域的MTL交互作用为正，而在物体提取任务中，MTL交互作用为负。涉及腹侧区域的相互作用显示出相反的模式。在知觉匹配过程中没有观察到类似的变化。使用对照模型，我们证明了这些结果的神经解剖学特异性。我们的结果支持这样的观点，即MTL和后部新皮质之间相互作用的性质取决于要恢复的信息域。
We applied structural equation modeling to positron emission tomography data in humans to examine functional interactions between the right medial temporal lobe (MTL) and selected right neocortical regions in relation to visual recognition memory. Using a priori knowledge about anatomical connections between these regions as a guiding constraint, we modeled the pattern of interactions [i.e. covariances in regional cerebral blood flow (rCBF)] associated with episodic memory retrieval of spatial location and compared it with the pattern for retrieval of object identity. We also compared these patterns with those associated with perceptual matching of spatial location and object identity. Although displaying no difference in average rCBF across tasks, the right MTL showed domain-specific qualitative differences in interactions with posterior dorsal (parieto-occipital sulcus, supramarginal gyrus) and ventral regions (fusiform gyrus, superior temporal sulcus) hut not with a prefrontal region. MTL interactions involving dorsal regions were positive in the spatial retrieval task but negative for object retrieval. Interactions involving ventral regions showed the reverse pattern. No comparable changes were observed during perceptual matching. Using control models, we demonstrated the neuroanatomical specificity of these results. Our results provide support for the notion that the nature of interactions between the MTL and posterior neocortex depends on the domain of information to-be recovered.