Surgical outcomes of multicentric adenocarcinomas of the biliary tract.
Surgical outcomes of multicentric adenocarcinomas of the biliary tract.
复制标题
胆道多中心腺癌的手术结果。
DOI：
10.1093/jjco/hyr103
复制
发表时间：
2011
影响因子：
2.4
通讯作者：
M. Kojima
中科院分区：
文献类型：
--
作者：
Shin Kobayashi;M. Konishi;Yuichiro Kato;N. Gotohda;Shinichirou Takahashi;T. Kinoshita;T. Kinoshitá;M. Kojima
客观的
与单一胆管癌相比，胆管多中心腺癌的独特特征尚不清楚。
方法
从1992年7月到2009年7月，393名患者在日本柏市国立癌症中心东医院接受了胆道癌手术。将多中心胆管腺癌的临床病理特征和手术结果与单一癌症进行比较。
结果
在此期间，393例胆道癌中发现10例（2.5%）多中心癌（6例同时性癌和4例异时性癌）。病理上，与单一癌症相比，多中心腺癌更可能是早期癌症，并且更可能是乳头状癌，同时有浅表上皮肿瘤扩散和广泛的不典型增生上皮，但发生淋巴结转移的可能性较小（P < 0.01）。早期乳头状癌中多中心癌的比例较高（9/24，37.5%）。临床上未发现淋巴结、腹膜或远处器官复发，但残余胆管有1例复发。只有一名患者死于癌症进展。多中心腺癌患者的总生存期在统计学上与单一癌症患者相同（中位生存期：69 个月与 30 个月，P = 0.47）。
结论
与单一癌症相比，胆道多中心腺癌具有明显的特征。
OBJECTIVE
In comparison to single biliary cancers, distinct features of biliary multicentric adenocarcinomas are not yet clear.
METHODS
From July 1992 to July 2009, 393 patients underwent surgery for cancers of the biliary tract at the National Cancer Center Hospital East, Kashiwa, Japan. Clinicopathological characteristics and surgical outcomes of multicentric biliary adenocarcinoma were compared with those of single cancers.
RESULTS
During the period, 10 cases (2.5%) with multicentric cancer (6 synchronous and 4 metachronous cancers) were found among 393 cases of biliary cancer. Pathologically, compared with single cancers, multicentric adenocarcinomas were more likely to be early cancers and to be papillary carcinomas with both superficial epithelial tumor spread and extensive dysplastic epithelium, but were less likely to have lymph node metastases (P < 0.01). The proportion of multicentric cancers among early papillary cancers was high (9/24, 37.5%). Clinically, no recurrences were detected in lymph nodes, peritoneum or distant organs, but one recurrence in the remnant bile duct. Only one patient died from cancer progression. The overall survival of patients with multicentric adenocarcinomas was statistically the same as that of single cancers (median survival: 69 vs. 30 months, P = 0.47).
CONCLUSIONS
Multicentric adenocarcinomas of the biliary tract have distinct features compared with single cancers.
影响因子：
2.4
作者：
Nakanuma, Yasuni;Sasaki, Motoko;Harada, Kenichi
通讯作者：
Harada, Kenichi