Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography
Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography
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DOI：
10.1117/1.jbo.21.6.065002
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发表时间：
2016-06-01
影响因子：
3.5
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Chen, Chieh-Li;Bojikian, Karine D.;Wang, Ruikang K.
光学相干断层扫描血管造影（OCTA）已日益成为临床上有用的眼科成像技术。我们评估使用基于光学微血管造影 (OMAG) 的 OCTA 测量的视神经乳头 (ONH) 血液灌注的重复性和再现性。招募 10 名健康志愿者的 10 只眼睛，并使用基于 68-kHz Cirrus HD-OCT 5000 的 OMAG 原型系统（卡尔蔡司 Meditec Inc.，都柏林，加利福尼亚州）扫描 3 次，该系统以 ONH 为中心，涉及六周内两次单独的访问。通过检测在同一视网膜位置获取的连续 B 扫描之间的 OCT 信号差异，使用 OMAG 处理生成血管图像。 ONH 灌注被量化为通量、血管面积密度和 ONH 内前层、筛板和完整 ONH 的标准化通量。变异系数（CV）和组内相关系数（ICC）用于评估访问内和访问间的重复性以及观察者间的再现性。 ONH 灌注测量显示出高重复性 [CV
Optical coherence tomography angiography (OCTA) has increasingly become a clinically useful technique in ophthalmic imaging. We evaluate the repeatability and reproducibility of blood perfusion in the optic nerve head (ONH) measured using optical microangiography (OMAG)-based OCTA. Ten eyes from 10 healthy volunteers are recruited and scanned three times with a 68-kHz Cirrus HD-OCT 5000-based OMAG prototype system (Carl Zeiss Meditec Inc., Dublin, California) centered at the ONH involving two separate visits within six weeks. Vascular images are generated with OMAG processing by detecting the differences in OCT signals between consecutive B-scans acquired at the same retina location. ONH perfusion is quantified as flux, vessel area density, and normalized flux within the ONH for the prelaminar, lamina cribrosa, and the full ONH. Coefficient of variation (CV) and intraclass correlation coefficient (ICC) are used to evaluate intravisit and inter-visit repeatability, and interobserver reproducibility. ONH perfusion measurements show high repeatability [CV