FIBROBLASTS IN NORMAL AND PATHOLOGICAL TERMINAL DIFFERENTIATION, AGING, APOPTOSIS AND TRANSFORMATION
FIBROBLASTS IN NORMAL AND PATHOLOGICAL TERMINAL DIFFERENTIATION, AGING, APOPTOSIS AND TRANSFORMATION
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DOI：
10.1016/s0167-4943(05)80006-8
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发表时间：
1992-01-01
影响因子：
4
通讯作者：
RODEMANN, HP
中科院分区：
文献类型：
--
作者：
BAYREUTHER, K;FRANCZ, PI;RODEMANN, HP
成纤维细胞群体一直被认为是同质的非分化细胞群体，直到今天。这种未定义的成纤维细胞群体已经成为一般细胞生物学、生物化学和病毒学以及更专门的问题如分化、衰老、凋亡和转化中定性和/或定量研究的主要细胞系统。从这些研究中获得的大多数数据都不一致，以至于许多科学家认为成纤维细胞系统不适合研究细胞群发育的分子机制。当用常规应用于干细胞系统中细胞的分子生物学研究的概念和方法进行分析时，已经证明Valo鸡、C3 H小鼠、BN大鼠和人的成纤维细胞系统是干细胞系统。在成纤维细胞干细胞系统中，在遗传程序的控制下，11种具有生物学和生物化学个体性的细胞类型在五个隔室中沿着沿着11个阶段的分化序列发育。这种分化序列在病理表现如杜氏肌营养不良、纤维化以及转化的、肿瘤转化的和回复突变的细胞谱系中的成纤维细胞群体中保持。越来越多的证据表明，所有的细胞系统都是干细胞系统，其设计类似于成纤维细胞干细胞系统的性质。如今，分子细胞生物学领域的研究采用非常先进的分子方法进行，但不幸的是，在大多数情况下，生物材料或细胞系统的定义不明确或不确定。
Fibroblast populations have been considered as homogeneous non-differentiating cell populations until nowadays. Such undefined fibroblast populations have been predominant cell systems for qualitative and/or quantitative studies in general cell biology, biochemistry and virology, and more specialized issues like differentiation, aging, apoptosis and transformation. Most data obtained from such investigations are inconsistent to such an extent, that many scientists consider the fibroblast cell system to be unsuited for studies of the molecular mechanisms of developing cell populations. When analyzed with concepts and methods routinely applied for the study of the molecular biology of cells in stem cell systems, it has been demonstrated, that fibroblast cell systems of Valo-chicken, C3H-mice, BN-rats, and man are stem cell systems. In the fibroblast stem cell system 11 cell-types with biological and biochemical individuality develop along a 11-stage differentiation sequence in five compartments under the control of genetic programs. This differentiation sequence is maintained in fibroblast populations in pathological manifestations, like Duchenne muscular dystrophy, fibrosis, as well as in transformed, neoplastically transformed, and revertant cell lineages. Evidence is accumulating, which makes it very likely, that all cell systems are stem cell systems with a design resembling the nature of the fibroblast stem cell system. Nowadays research in the field of molecular cell biology is undertaken with very advanced molecular methods, but unfortunately in most instances with poorly defined or undefined biological material or cell systems.