Integrin Regulation during Leukocyte Recruitment
Integrin Regulation during Leukocyte Recruitment
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DOI：
10.4049/jimmunol.1203179
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发表时间：
2013-05-01
影响因子：
4.4
通讯作者：
Zarbock, Alexander
中科院分区：
文献类型：
--
作者：
Herter, Jan;Zarbock, Alexander
整合素被认为是白细胞募集的重要角色。整合素功能障碍会导致严重的疾病模式，其特征是无法对抗病原体。虽然炎症反应对宿主防御是有益的，也是必要的，但必须控制这些反应，以防止组织破坏和有害的后遗症。在这篇综述中，我们讨论了导致中性粒细胞、单核细胞和淋巴细胞整合素粘附性改变的不同信号通路。因此，我们侧重于整合素激活对于白细胞募集级联反应的不同步骤的重要性，包括滚动、黏附、黏附后加强、血管内爬行和移行，因为每一步都需要一组独特的整合素分子的正确功能，而整合素分子必须被特定地激活。此外，我们还讨论了平衡和抵消整合素激活以及限制炎症部位白细胞募集的内源性机制。对这些复杂机制的进一步了解可能为开发新的抗炎疗法提供新的途径。免疫学杂志，2013,190：4451-4457。
Integrins are recognized as vital players in leukocyte recruitment. Integrin malfunction causes severe disease patterns characterized by the inability to fight pathogens. Although inflammatory reactions are beneficial and necessary for host defense, these reactions have to be controlled to prevent tissue destruction and harmful sequelae. In this review, we discuss the different signaling pathways leading to the change of integrin adhesiveness in neutrophils, monocytes, and lymphocytes. We thereby focus on the importance of integrin activation for the different steps of the leukocyte recruitment cascade, including rolling, adhesion, postadhesion strengthening, intravascular crawling, and transmigration, as each step necessitates the proper functioning of a distinct set of integrin molecules that has to be activated specifically. Additionally, we discuss endogenous mechanisms that balance and counteract integrin activation and limit leukocyte recruitment at the site of inflammation. Further insight into these complex mechanisms may provide new approaches for developing new anti-inflammatory therapies. The Journal of Immunology, 2013, 190: 4451-4457.