Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
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DOI：
10.1017/s1461145705005481
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发表时间：
2006-02-01
影响因子：
4.8
通讯作者：
Ozaki, N
中科院分区：
文献类型：
--
作者：
Ikeda, M;Iwata, N;Ozaki, N
最近的证据表明，AKT 1-GSK 3 β信号级联部分介导多巴胺依赖性行为。在精神分裂症或甲基苯丙胺（Methe）使用障碍的病理生理学方面，AKT 1是此类疾病的良好候选基因。对于精神分裂症，在美国和日本样本中报告了SNP和AKT 1单倍型的正相关。为了评估AKT 1和甲基苯丙胺使用障碍之间的关联，我们对日本样本（182例患者和437例对照）进行了病例对照研究。发现SNP和单倍型之间存在正相关，并且“信号”SNP与发现与美国精神分裂症相关的SNP相同，但与日本精神分裂症无关。我们的研究结果表明，AKT 1可能发挥作用，在发展中的甲基使用障碍。这些协会的进一步调查，以及从以前的动物研究的证据可能会打开的方式来阐明这种情况下的病理生理学。
Recent evidence suggests that the AKT1-GSK3 beta signalling cascade partially mediates dopamine-dependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the 'signal' SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies may open the way to elucidation of the pathophysiology of this condition.