Selective alteration of personality and social behavior by serotonergic intervention
Selective alteration of personality and social behavior by serotonergic intervention
复制标题
DOI：
10.1176/ajp.155.3.373
复制
发表时间：
1998-03-01
影响因子：
17.7
通讯作者：
Reus, VI
中科院分区：
文献类型：
--
作者：
Knutson, B;Wolkowitz, OM;Reus, VI
目的：作者试图检验因果关系假设，即多巴胺能连接调节人类情感体验和社会行为的个体差异的正常谱的各个方面。方法：选择性5-羟色胺再摄取抑制剂（SSRI），帕罗西汀，20毫克/天（N=26），或安慰剂（N=25），以双盲方式给予正常志愿者4周，并在基线和治疗的第1周和第4周的个性变量和社会行为进行了评估。结果如下：相对于安慰剂，SSRI给药I通过更普遍的负面情绪下降来引出敌意的焦点指数，但并没有改变积极情绪的指数。此外，SSRI管理增加了社会关系的行为指数。在实验结束时，负性情感和亲和行为的变化与志愿者血浆SSRI水平显著相关。结论：中枢多巴胺能功能可以调节正常人格的一个维度，其特征是减少负面情感体验和增加亲和行为。SSRI给药对这些指标有显著和可检测的影响，即使在没有基线临床抑郁或其他精神病理学的情况下。
Objective: The authors sought to test the causal hypothesis that serotonergic Junction modulates aspects of the normal spectrum of individual differences in affective experience and social behavior in humans. Method: A selective serotonin reuptake inhibitor (SSRI), paroxetine, 20 mg/day (N=26), or placebo (N=25) was administered to normal volunteers in a double-blind manner for 4 weeks, and personality variables and social behavior were assessed at baseline and at weeks 1 and 4 of treatment. Results: Relative to placebo, SSRI administration I educed focal indices of hostility through a more general decrease in negative affect, yet did not alter indices of positive affect. In addition, SSRI administration increased a behavioral index of social affiliation. Changes in both negative affect and affiliative behavior were significantly related to volunteers' plasma SSRI levels at the end of the experiment. Conclusions: Central serotonergic function may modulate a dimension of normal personality characterized by reduced negative affective experience and increased affiliative behavior. SSRI administration has significant and detectable effects on these measures even in the absence of baseline clinical depression or other psychopathology.