Direct Cross-Coupling of Allylic C(sp3)-H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis
Direct Cross-Coupling of Allylic C(sp3)-H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis
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DOI：
10.1002/anie.201805118
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发表时间：
2018-08-06
影响因子：
16.6
通讯作者：
Rueping, Magnus
中科院分区：
文献类型：
--
作者：
Huang, Long;Rueping, Magnus
在镍和可见光催化下，研究了未活化的三取代和四取代烯烃的烯丙基C(sp(3))-H键的直接活化及其与芳基和乙烯基溴的官能化反应。该方法允许在温和的反应条件下生成C(sp(2))-C(sp(3))，具有良好的官能团耐受性和良好的区域选择性。
An efficient protocol for the direct allylic C(sp(3))-H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp(2))-C(sp(3)) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.