Direct synthesis of functional azaxanthones by using a domino three-component reaction.
Direct synthesis of functional azaxanthones by using a domino three-component reaction.
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DOI：
10.1021/ol3013099
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发表时间：
2012-06
期刊：
影响因子：
5.2
通讯作者：
Jianwei Yan;Ming Cheng;Feng Hu;Youhong Hu
中科院分区：
文献类型：
--
作者：
Jianwei Yan;Ming Cheng;Feng Hu;Youhong Hu
NH 醛亚胺是由相应的醛与乙酸铵反应原位生成的，在与 3-(1-炔基)色酮和 3-氰基色酮反应中充当氮亲核试剂，生成官能化的氮杂蒽酮。这些过程在温和条件下进行，不需要干燥溶剂。所述反应的产物代表新的化学实体。我们相信，新开发的级联工艺将成为合成 N-杂环和面向多样性的合成的有效方法。
NH aldimines, generated in situ from the corresponding aldehydes by reaction with ammonium acetate, serve as nitrogen nucleophiles in reactions with 3-(1-alkynyl)chromones and 3-cyanochromones that generate functionalized azaxanthones. These processes take place under mild conditions that do not require dry solvents. The products of the reactions described represent new chemical entities. We believe that the newly developed cascade process will serve as a potent method for the synthesis of N-heterocycles and in diversity-oriented synthesis.