Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over
Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over
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DOI：
10.1017/s0007114508901240
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发表时间：
2008-09-01
影响因子：
3.6
通讯作者：
Lanham-New, Susan A.
中科院分区：
文献类型：
--
作者：
Gannon, Richard H. T.;Millward, D. Joe;Lanham-New, Susan A.
在严格控制的条件下，膳食摄入已被证明会影响人体的酸碱平衡。然而，食物类别对人群中碱/酸负荷的净效应尚不清楚。本研究的目的是：（1）对65岁及以上具有代表性的英国老年人群体每日净内源性酸产生量（NEAP）（毫当量/天）进行量化估计；（2）通过可能影响膳食酸负荷的特定营养素和食物类别对NEAP进行比较和描述；（3）确定地理位置是否影响NEAP。使用由4天称重记录和人体测量数据组成的英国国家膳食与营养调查数据集来估计膳食酸度。通过仅分析能量摄入≥1.2×基础代谢率的受试者，排除膳食摄入报告不足者。NEAP估计为膳食潜在肾酸负荷 + 有机酸排泄量，后者是估计体表面积的倍数。女性的NEAP低于男性（P < 0.001），且低于瑞典老年队列中所报告的值。较低的膳食酸度与较高的水果和土豆摄入量以及较低的肉类、面包和鸡蛋摄入量显著相关（P < 0.02至P < 0.001）。较低的鱼类和奶酪摄入量仅与男性较低的NEAP相关（P < 0.01至P < 0.001）。NEAP存在地区差异，苏格兰/北部地区的摄入量高于中部/西南部和伦敦/东南部地区（P = 0.01）。这些数据深入了解了英国老年人群膳食的产酸潜力，这可能对这一弱势群体产生重要影响。
Dietary intake has been shown to influence acid-base balance in human subjects under tightly controlled conditions. However, the net effect of food groups on alkali/acid loading in population groups is unclear. The aims of the present study were to: (1) quantify estimates of daily net endogenous acid production (NEAP) (mEq/d) in a representative group of British elderly aged 65 years and older; (2) compare and characterise NEAP by specific nutrients and food groups likely to influence dietary acid loading; (3) determine whether geographical location influenced NEAR The National Diet and Nutrition Survey dataset, consisting of a 4d weighed record and anthropometric data, was used to estimate dietary acidity. Dietary under-reporters were excluded by analysing only subjects with energy intakes >= 1.2 X BMR. NEAP was estimated as the dietary potential renal acid load + Organic acid excretion, the latter as a multiple of estimated body surface area. NEAP was lower in women compared with men (P < 0.001), and lower than values reported in a Swedish elderly cohort. Lower dietary acidity was significantly associated with higher consumption of fruit and potatoes and lower consumption of meat, bread and eggs (P < 0.02 to P < 0.001). Lower intakes of fish and cheese were associated with lower NEAP in men only (P < 0.01 to P < 0.001). There were regional differences for NEAP, with higher intakes in Scotland/ Northern regions compared with Central/South-Western and London/South-Eastern regions (P=0.01). These data provide an insight into the acid-generating potential of the diet in the British elderly population, which may have important consequences in this vulnerable group.