TRYPTOPHAN AVAILABILITY AND SEROTONIN SYNTHESIS
TRYPTOPHAN AVAILABILITY AND SEROTONIN SYNTHESIS
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DOI：
10.1079/pns19870018
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发表时间：
1987-02-01
影响因子：
7
通讯作者：
LEATHWOOD, PD
中科院分区：
文献类型：
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作者：
LEATHWOOD, PD
一般来说，大脑TRP增加一倍（大约从下午15点到30点）会使大脑gHT和5HIAA增加2-30% （Fernstrom & Wurtman, 1972; Fernstrom et al. 1974; Arimanana et al. 1984）。当脑色氨酸接近90 PM（色氨酸单加氧酶应达到饱和的浓度）时，剂量-反应曲线趋于平缓。Young和Gauthier（1981）的结果表明，类似的饱和也可能发生在男性身上，因为3 g TRP负荷大约使CSF 5HIAA加倍，而6 g负荷不会进一步增加。
In general, it appears that a doubling of brain TRP (from about 15 to 30 PM) produces a 2-30% rise in brain gHT and 5HIAA (Fernstrom & Wurtman, 1972; Fernstrom et al. 1974; Arimanana et al. 1984). The dose-response curve flattens off as brain TRP approaches 90 PM (the concentration at which TRP ymonooxygenase should be saturated). The results of Young & Gauthier (1981) suggest that a similar saturation may also occur in man since a 3 g load of TRP approximately doubles CSF 5HIAA while a 6 g load produces no further increase.