Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy.
Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy.
复制标题
DOI：
10.1289/ehp.6864
复制
发表时间：
2004-08
影响因子：
10.4
通讯作者：
Nakazawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Inoue, Koichi;Okada, Fumio;Ito, Rie;Kato, Shizue;Sasaki, Seiko;Nakajima, Sonomi;Uno, Akiko;Saijo, Yasuaki;Sata, Fumihiro;Yoshimura, Yoshihiro;Kishi, Reiko;Nakazawa, Hiroyuki
含氟有机化合物（FOCs），如全氟辛烷磺酸（PFOS）、全氟辛酸盐（PFOA）和全氟辛烷磺酰酰胺（PFOSA），广泛用于制造塑料、电子产品、纺织品和服装、皮革和室内装潢行业的建筑材料。已在人类血液样本中检测到FOCs。研究表明，FOCs可能通过影响甲状腺激素水平对啮齿动物的发育有害。在本研究中，我们测定了母体和脐带血样本中FOCs的浓度。17-37岁的孕妇被纳入研究对象。采用液相色谱-电喷雾质谱联用在线萃取法对15对产妇和脐带血样品中的FOCs进行了分析。人血浆或血清中PFOS、PFOA和PFOSA的定量限分别为0.5、0.5和1.0 ng/mL。该方法能够精确测定FOCs，并可用于检测人类血液样本中的FOCs，以监测人类接触情况。母体样本中的全氟辛烷磺酸浓度为4.9至17.6纳克/毫升，而胎儿样本中的全氟辛烷磺酸浓度为1.6至5.3纳克/毫升。相比之下，胎儿或母体样本中未检测到PFOSA，而PFOA仅在母体样本中检测到（范围< 0.5至2.3 ng/mL, 4 / 15）。我们的研究结果显示母体和脐带血中全氟辛烷磺酸浓度高度相关（r2 = 0.876）。然而，我们没有发现母体和脐带血样本中全氟辛烷磺酸浓度与年龄、出生体重、促甲状腺激素或游离甲状腺素水平之间有任何显著相关性。我们的研究表明，日本的人类胎儿可能暴露于相对较高水平的foc。需要进一步调查以确定胎儿暴露于foc的产后影响。
Fluorinated organic compounds (FOCs), such as perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorooctane sulfonylamide (PFOSA), are widely used in the manufacture of plastic, electronics, textile, and construction material in the apparel, leather, and upholstery industries. FOCs have been detected in human blood samples. Studies have indicated that FOCs may be detrimental to rodent development possibly by affecting thyroid hormone levels. In the present study, we determined the concentrations of FOCs in maternal and cord blood samples. Pregnant women 17–37 years of age were enrolled as subjects. FOCs in 15 pairs of maternal and cord blood samples were analyzed by liquid chromatography–electrospray mass spectrometry coupled with online extraction. The limits of quantification of PFOS, PFOA, and PFOSA in human plasma or serum were 0.5, 0.5, and 1.0 ng/mL, respectively. The method enables the precise determination of FOCs and can be applied to the detection of FOCs in human blood samples for monitoring human exposure. PFOS concentrations in maternal samples ranged from 4.9 to 17.6 ng/mL, whereas those in fetal samples ranged from 1.6 to 5.3 ng/mL. In contrast, PFOSA was not detected in fetal or maternal samples, whereas PFOA was detected only in maternal samples (range, < 0.5 to 2.3 ng/mL, 4 of 15). Our results revealed a high correlation between PFOS concentrations in maternal and cord blood (r2 = 0.876). However, we did not find any significant correlations between PFOS concentration in maternal and cord blood samples and age bracket, birth weight, or levels of thyroid-stimulating hormone or free thyroxine. Our study revealed that human fetuses in Japan may be exposed to relatively high levels of FOCs. Further investigation is required to determine the postnatal effects of fetal exposure to FOCs.