Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children
Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children
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DOI：
10.1289/ehp.021100787
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发表时间：
2002-12-01
影响因子：
10.4
通讯作者：
Thompson, B
中科院分区：
文献类型：
--
作者：
Curl, CL;Fenske, RA;Thompson, B
我们分析了华盛顿州农业社区218个农场工人家庭的有机磷农药暴露情况，以调查农药暴露的回家途径，并为社区干预项目建立基线暴露水平。房屋灰尘样本（n = 156），从家庭内收集;和车辆灰尘样本（n = 190），从所使用的车辆的农场工人上下班。从每个家庭的一名农场工人（n = 213）和一名幼儿（n = 211）中获得尿样。粉尘样品进行了分析，六种农药，尿液样品进行了分析，五个二烷基磷酸盐（DAP）的代谢物。甲基噻嗪酮的检出浓度（p < 0.0001）高于其他农药：甲基噻嗪酮的几何平均浓度在房屋灰尘中为0.53 μg/g，在车辆灰尘中为0.75 μg/g。在儿童和成人尿液中，二甲基DAP代谢物浓度均高于二乙基DAP代谢物浓度（p < 0.0001）。成人尿液中二甲基DAP浓度的几何平均值为0.13 mumol/L，儿童尿液中为0.09 mumol/L。肌酐校正的几何平均二甲基DAP浓度为0.09 μ mol/g成人尿液和0.14 μ mol/g儿童尿液。来自同一家庭的房屋灰尘和车辆灰尘中的甲基喹嗪草浓度显著相关（r（2）= 0.41，p < 0.0001）。来自同一家庭的儿童和成人尿液中的二甲基DAP水平也显著相关（r（2）= 0.18，p < 0.0001），并且当值被肌酐校正时，这种关联仍然存在。这项工作的结果支持了这一假设，即带回家的接触途径有助于住宅农药污染的农业家庭，幼儿的存在。
We analyzed organophosphorus pesticide exposure in 218 farm worker households in agricultural communities in Washington State to investigate the take-home pathway of pesticide exposure and to establish baseline exposure levels for a community intervention project. House dust samples (n = 156) were collected from within the homes; and vehicle dust samples (n = 190) were collected from the vehicles used by the farm workers to commute to and from work. Urine samples were obtained from a farm worker (n = 213) and a young child (n = 211) in each household. Dust samples were analyzed for six pesticides, and urine samples were analyzed for five dialkylphosphate (DAP) metabolites. Azinphosmethyl was detected in higher concentrations (p < 0.0001) than the other pesticides: geometric mean concentrations of azinphosmethyl were 0.53 μg/g in house dust and 0.75 μg/g in vehicle dust. Dimethyl DAP metabolite concentrations were higher than diethyl DAP metabolite concentrations in both child and adult urine (p < 0.0001). Geometric mean dimethyl DAP concentrations were 0.13 mumol/L in adult urine and 0.09 mumol/L in child urine. Creatinine-adjusted geometric mean dimethyl DAP concentrations were 0.09 mumol/g in adult urine and 0.14 mumol/g in child urine. Azinphosmethyl concentrations in house dust and vehicle dust from the same household were significantly associated (r(2) = 0.41, p < 0.0001). Dimethyl DAP levels in child and adult urine from the same household were also significantly associated (r(2) = 0.18, p < 0.0001), and this association remained when the values were creatinine adjusted. The results of this work support the hypothesis that the take-home exposure pathway contributes to residential pesticide contamination in agricultural homes where young children are present.