AVOIDANCE OF GASTRODUODENAL TOXICITY IN PATIENTS RECEIVING HEPATIC ARTERIAL 5-FLUORO-2-DEOXYURIDINE
AVOIDANCE OF GASTRODUODENAL TOXICITY IN PATIENTS RECEIVING HEPATIC ARTERIAL 5-FLUORO-2-DEOXYURIDINE
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DOI：
10.1200/jco.1985.3.9.1257
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发表时间：
1985-01-01
影响因子：
45.3
通讯作者：
LEWIS, BJ
中科院分区：
文献类型：
--
作者：
HOHN, DC;STAGG, RJ;LEWIS, BJ
在接受5-氟-2‘’-脱氧尿苷(FUDR)持续肝动脉灌注治疗肝脏恶性肿瘤的患者中，胃十二指肠炎症和溃疡是常见的。35例转移性结肠癌患者接受了埋藏式输液泵肝动脉FUDR检查。在手术中，要特别注意识别和分离来自肝动脉的血管，这些血管来自供应远端胃和近端十二指肠上缘的插管点的远端肝动脉。所有患者均未出现因化疗引起的胃炎或溃疡的体征或症状。我们认为，接受肝动脉FUDR的患者的胃炎和溃疡是由于药物误灌入上消化道所致，通过使用适当的手术技术，这些并发症在很大程度上是可以避免的。
Gastroduodenal inflammation and ulceration have been frequently observed in patients receiving continuous hepatic arterial infusions of 5-fluoro-2''-deoxyuridine (FUDR) for liver malignancy. Thirty-five patients with metastatic colon cancer received hepatic arterial FUDR administered with implanted infusion pumps. At surgery, particular care was taken to identify and divide those vessels arising from the hepatic arteries distal to the point of cannulation that supplied the superior border of the distal stomach and proximal duodenum. None of the patients developed signs or symptoms of gastritis or ulcer attributable to chemotherapy. We contend that gastritis and ulcer in patients receiving hepatic arterial FUDR are due to misperfusion of drug into the upper gastrointestinal tract and that these complicatons can be largely avoided by use of appropriate surgical techniques.