Maternal transfer of photoperiodic information in Siberian hamsters. III. Melatonin injections program postnatal reproductive development expressed in constant light.
Maternal transfer of photoperiodic information in Siberian hamsters. III. Melatonin injections program postnatal reproductive development expressed in constant light.
复制标题
西伯利亚仓鼠光周期信息的母体传递。
DOI：
10.1095/biolreprod41.1.34
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发表时间：
1989
影响因子：
3.6
通讯作者：
Stetson,MH
中科院分区：
文献类型：
--
作者：
Horton,TH;Ray,SL;Stetson,MH
在西伯利亚仓鼠中，光周期信息从母鼠到胎儿的传递会影响幼鼠的青春期睾丸发育，无论是在恒定光照 (LL) 下还是在出生后中等长度的光周期（即 14L:10D）下饲养。怀孕期间短光周期的影响可以通过给怀孕女性服用褪黑激素来模拟。该实验检验了当松果体完整、长期光照的怀孕雌性服用褪黑素时，是否存在每日对褪黑素敏感的模式。怀孕和哺乳期女性群体在一天中的每个小时都接受褪黑激素。年轻人没有接受外源性褪黑激素治疗。在其内源性松果体褪黑激素节律大致成熟的时间（第15天），幼崽被置于LL状态以抑制松果体褪黑激素的分泌。年轻雄性在28天大时被杀死。下午（1200 小时至 2000 小时）和深夜（0400 小时）向雌性注射褪黑激素，导致其雄性幼崽发育，就好像妊娠发生在短光周期内一样。其他时间注射褪黑激素无效。对怀孕雌性施用外源性褪黑激素的每日有效性模式与在该仓鼠和其他仓鼠物种的成年雄性中观察到的效果相似，并且与褪黑激素敏感性的每日节律参与光周期信号的转导的假设一致。
In Siberian hamsters, transference of photoperiodic information from dam to fetus influences pubertal testicular development of the young when reared either in constant light (LL) or postnatal photoperiods of intermediate length (i.e. 14L:10D). The effects of short photoperiods during gestation can be mimicked by administering melatonin to pregnant females. This experiment examined whether there exists a daily pattern of sensitivity to melatonin when it is administered to pineal-intact pregnant females housed on a long photoperiod. Groups of pregnant and lactating females received melatonin at each hour of the day. The young were not treated with exogenous melatonin. At the approximate time of maturation of their endogenous pineal melatonin rhythm (Day 15), the young were placed in LL to suppress pineal melatonin secretion. Young males were killed at 28 days of age. Afternoon (1200 h–2000 h) and late night (0400 h) injections of melatonin into females caused their male young to develop as though gestation occurred on a short photoperiod. Melatonin injections at other times were ineffective. The daily pattern of effectiveness of exogenous melatonin administration to pregnant females resembles that observed in adult males of this and other hamster species and is consistent with the hypothesis that a daily rhythm in sensitivity to melatonin is involved in the transduction of photoperiodic signals.