Derivation of an occupational exposure level for manganese in welding fumes
Derivation of an occupational exposure level for manganese in welding fumes
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DOI：
10.1016/j.neuro.2017.06.009
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发表时间：
2018-01-01
期刊：
影响因子：
3.4
通讯作者：
Goodman, Julie E.
中科院分区：
文献类型：
--
作者：
Bailey, Lisa A.;Kerper, Laura E.;Goodman, Julie E.
已知在职业环境中暴露于高水平的锰（Mn）会导致不良的神经影响。由于锰是一种必需的营养素，因此存在维持其体内稳态控制的机制，并且空气中存在一定水平的锰，其不会扰乱锰的体内稳态。然而，在职业环境中预期无不良影响的锰暴露浓度在监管机构之间差异很大。我们着手推导焊工的锰职业暴露水平（OEL），基于对评估焊接烟雾中锰暴露浓度的研究的综述，以及：（1）焊工的神经系统影响;（2）焊工大脑中的锰水平（通过磁共振成像[MRI]估计的苍白球指数[PI]）;（3）焊工中锰暴露的其他生物标志物（即，血液和尿液）;和（4）Mn脑浓度，PI，以及非人灵长类动物中相应的神经学效应。我们的分析表明，从许多职业焊接研究中量化锰的剂量反应关联的不确定性。少数焊接研究充分估计了暴露量，表明可吸入锰的可能OEL为100-140 μ g/m3。这一范围与其他流行病学研究、焊工锰暴露生物标志物研究以及非人灵长类动物研究一致，但未来的研究可能为焊工锰职业指南的制定提供更有力的依据。(C)2017爱思唯尔B. V.保留所有权利。
Exposure to high levels of manganese (Mn) in occupational settings is known to lead to adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that maintain its homeostatic control in the body, and there is some level of Mn in air that does not perturb Mn homeostasis. However, the Mn exposure concentrations at which no adverse effects are expected in occupational settings vary considerably across regulatory agencies. We set out to derive a Mn Occupational Exposure Level (OEL) for welders based on a review of studies that evaluated Mn exposure concentrations from welding fumes and: (1) neurological effects in welders; (2) levels of Mn in the brains of welders (via pallidal index [PI] estimated from magnetic resonance imaging [MRI]); (3) other biomarkers of Mn exposure in welders (i.e., blood and urine); and (4) Mn brain concentrations, PI, and corresponding neurological effects in non-human primates. Our analysis suggests uncertainty in quantifying dose-response associations for Mn from many of the occupational welding studies. The few welding studies that adequately estimate exposure suggest a possible OEL of 100-140 mu g/m(3) for respirable Mn. This range is consistent with other epidemiology studies, studies of biomarkers of Mn exposure in welders, and with studies in non-human primates, though future studies could provide a stronger basis for deriving a Mn occupational guideline for welders. (C) 2017 Elsevier B.V. All rights reserved.