Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis
Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis
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DOI：
10.1136/jnnp.2009.177733
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发表时间：
2010-04-01
影响因子：
11
通讯作者：
Gallo, Paolo
中科院分区：
文献类型：
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作者：
Calabrese, Massimiliano;Mattisi, Irene;Gallo, Paolo
目的分析多发性硬化（MS）患者小脑皮质体积（CCV）和脑白质病变（CL）及其对临床功能的影响。35例复发缓解型多发性硬化（RRMS），27例继发进展型多发性硬化（SPMS），25例原发进展型多发性硬化，32例正常对照（NC）。分别用Freesurfer软件和Double Inversion Recovery软件计算CCV和小脑CL的数量和体积（平均113.2 +/- 2.6 cm（3）），CIS患者的CCV显著降低（105.4 +/- 2.2 cm（3），p=0.018），RRMS（104.0 +/- 2.0 cm（3），p=0.012），SPMS（98.8 +/- 2.0 cm（3），p
Background Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in multiple sclerosis (MS), only a few MRI studies on cerebellar cortical pathology in MS are available.Objective To analyse cerebellar cortical volume (CCV) and leucocortical lesions (CL) in MS, and their impact on clinical disability.Methods The authors studied 125 patients divided into 38 Clinical Isolated Syndrome (CIS), 35 relapsing remitting multiple sclerosis (RRMS), 27 secondary progressive multiple sclerosis (SPMS) and 25 primary progressive multiple sclerosis, and 32 normal controls (NC). CCV and cerebellar CL number and volume were evaluated by means of Freesurfer software and Double Inversion Recovery, respectively.Results Compared with NC (mean 113.2 +/- 2.6 cm(3)), the CCV was significantly reduced in CIS (105.4 +/- 2.2 cm(3), p=0.018), RRMS (104.0 +/- 2.0 cm(3), p=0.012), SPMS (98.8 +/- 2.0 cm(3), p