The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats
The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats
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DOI：
10.1016/j.physbeh.2005.08.004
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发表时间：
2005-10-15
影响因子：
2.9
通讯作者：
Eckel, LA
中科院分区：
文献类型：
--
作者：
Rivera, HM;Eckel, LA
芬氟拉明（一种5-羟色胺（5-HT）拮抗剂）在性和发情周期中出现的厌食效果差异，促使我们研究这些行为变化是否由雌二醇介导。老鼠被切除卵巢，关在笼子里，允许通过自动化的计算机系统分析进食和运动活动。采用受试者内设计，研究了1 mg/kg d-芬氟拉明和生理盐水载体对去卵巢大鼠在雌二醇苯甲酸酯（estradiol benzoate， EB）和油载体治疗后进食和轮跑的影响。采用EB循环治疗方案模拟大鼠4天发情周期内源性雌二醇分泌的变化。与油处理的大鼠相比，eb处理的大鼠在芬氟拉明处理后食物摄入量的减少更大。芬氟拉明还能使去卵巢大鼠的车轮跑速减少，但幅度小，但效果显著，不受EB治疗的影响。因此。EB增加这种剂量芬氟拉明的厌食效果的能力似乎是行为特异性的。尽管芬氟拉明对食物摄入的抑制在很大程度上归因于其增加突触5-HT水平的能力，但需要更多涉及选择性5-HT受体激动剂和拮抗剂的研究来确定雌二醇是否与内源性5-HT系统相互作用以控制雌性大鼠的食物摄入。(c) 2005爱思唯尔公司版权所有。
The emergence of sex- and estrous cycle-related differences in the anorectic effect of fenfluramine, a serotonin (5-HT) agoinst, prompted us to investigate whether these behavioral changes are mediated by estradiol. Rats were ovariectomized and housed in cages that permitted the analysis of feeding and locomotor activity via an automated, computerized system. Using a within-subjects design, we investigated the effects of 1 mg/kg d-fenfluramine and saline vehicle on food intake and wheel running in ovariectomized rats following estradiol benzoate (EB) and oil vehicle treatment. A cyclic regimen of EB treatment was used to mimic the changes in endogenous estradiol secretion over the rat's 4-day estrous cycle. The decrease in food intake following fenfluramine treatment was greater in EB-treated rats, relative to oil-treated rats. Fenfluramine also produced a small but significant decrease in wheel running in ovariectomized rats that was not modulated by EB treatment. Thus. EB's ability to increase the anorectic effect of this dose of fenfluramine appears behaviorally specific. Although the inhibition of food intake by fenfluramine is largely attributed to its ability to increase synaptic levels of 5-HT, additional research involving selective 5-HT receptor agonists and antagonists is necessary to determine whether estradiol interacts with the endogenous 5-HT system to control food intake in the female rat. (c) 2005 Elsevier Inc. All rights reserved.