Iron and iron-based alloys for temporary cardiovascular applications
Iron and iron-based alloys for temporary cardiovascular applications
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DOI：
10.1007/s10856-015-5473-8
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发表时间：
2015-03-01
影响因子：
3.7
通讯作者：
Boccaccini, A. R.
中科院分区：
文献类型：
--
作者：
Francis, A.;Yang, Y.;Boccaccini, A. R.
在过去的十年中，可生物降解金属已经成为需要高强度体积比的特定生物医学应用的一个感兴趣的主题，包括心血管支架。可生物降解材料的优势在于减少与永久性金属植入物相关的长期风险，例如慢性炎症和支架内再狭窄。从结构的角度来看，对文献的分析表明，作为临时可生物降解支架的铁基合金在延展性和强度方面比镁基合金有几个优势。对铁基合金设计和成分的改性和可调性的研究主要集中在控制铁基合金的降解速率，同时在合理的时间内保持铁基合金的机械完整性。许多铁基合金的早期临床前结果似乎对未来植入物的发展很有希望。本文综述了现有的文献，主要集中在：(i)铁和铁基合金的设计和制造技术；（ii）体外和体内性能；（三）细胞毒性和细胞活力试验。
In the last decade, biodegradable metals have emerged as a topic of interest for particular biomedical applications which require high strength to bulk ratio, including for cardiovascular stents. The advantages of biodegradable materials are related to the reduction of long term risks associated with the presence of permanent metal implants, e.g. chronic inflammation and in-stent restenosis. From a structural point of view, the analysis of the literature reveals that iron-based alloys used as temporary biodegradable stents have several advantages over Mg-based alloys in terms of ductility and strength. Efforts on the modification and tunability of iron-based alloys design and compositions have been mainly focused on controlling the degradation rate while retaining the mechanical integrity within a reasonable period. The early pre-clinical results of many iron-based alloys seem promising for future implants developments. This review discusses the available literature focusing mainly on: (i) Fe and Fe-based alloys design and fabrication techniques; (ii) in vitro and in vivo performance; (iii) cytotoxicity and cell viability tests.